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Development and Investigation of mouse models of deep brain stimulation for self-injurious behaviours in Autism Spectrum Disorder
https://braincanada.ca/funded-grants/development-and-investigation-of-mouse-models-of-deep-brain-stimulation-for-self-injurious-behaviours-in-autism-spectrum-disorderThere is a pressing unmet need to develop novel therapies for children with Autism Spectrum Disorder (ASD) and self-injurious behaviours (SIB). Project Overview Shireen and Edna Marcus Excellence Award There is a pressing unmet need to develop novel therapies for children with Autism Spectrum...
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Development and testing of a system for remote ischemic conditioning in preparation for clinical trials in cerebral small vessel disease and pre-hospital stroke care
https://braincanada.ca/funded-grants/development-and-testing-of-a-system-for-remote-ischemic-conditioning-in-preparation-for-clinical-trials-in-cerebral-small-vessel-disease-and-pre-hospital-stroke-careOne in four strokes are caused by a condition called cerebral small vessel disease (CSVD). There are no approved treatments for CSVD. Project Overview One in four strokes are caused by a condition called cerebral small vessel disease (CSVD). There are no approved treatments for CSVD. There also no...
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Development and validation of reagent kits for commercial high-throughput screening of PPI s and PPI inhibitors
https://braincanada.ca/funded-grants/development-and-validation-of-reagent-kits-for-commercial-high-throughput-screening-of-ppi-s-and-ppi-inhibitorsMembrane proteins are biological molecules of incredible importance, playing diverse roles in many processes critical to life. Project Overview Membrane proteins are biological molecules of incredible importance, playing diverse roles in many processes critical to life. Improper function of...
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Development of a caregiver reported and weighted dementia outcome
https://braincanada.ca/funded-grants/development-of-a-caregiver-reported-and-weighted-dementia-outcomeCaregivers of people living with dementia know the person the best and have direct experience of how their partner’s dementia is progressing. Project Overview Caregivers of people living with dementia know the person the best and have direct experience of how their partner’s dementia is...
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Development of a diagnostic amyloid-β seed amplification assay to discriminate between Alzheimer’s disease with and without cerebral amyloid angiopathy
https://braincanada.ca/funded-grants/development-of-a-diagnostic-amyloid-β-seed-amplification-assay-to-discriminate-between-alzheimer-s-disease-with-and-without-cerebral-amyloid-angiopathyIn Alzheimer’s disease (AD), the pathogenic amyloid-beta protein accumulates in the brain parenchyma and vessel walls. Project Overview In Alzheimer’s disease (AD), the pathogenic amyloid-beta protein accumulates in the brain parenchyma and vessel walls. Deposition of amyloid-beta in the brain...
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Development of a high throughput 3D microphysiologicalplatform for rapid automated assessment of human brain organoids response to drugs targeting neurological disorders
https://braincanada.ca/funded-grants/development-of-a-high-throughput-3d-microphysiologicalplatform-for-rapid-automated-assessment-of-human-brain-organoids-response-to-drugs-targeting-neurological-disordersAlzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common and devastating neurological diseases, with over 750,000 AD patients and over 100,000 PD patients in Canada. Project Overview Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common and devastating...
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Development of a shared decision-making aid for bulbar symptom management in ALS
https://braincanada.ca/funded-grants/development-of-a-shared-decision-making-aid-for-bulbar-symptom-management-in-alsBulbar disease, which affects speech and swallowing functions, is considered to be one of the most debilitating aspects of ALS by patients. Project Overview Bulbar disease, which affects speech and swallowing functions, is considered to be one of the most debilitating aspects of ALS by patients. It...
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Development of Genetic Screening Platforms for Immune Evasion in Glioblastoma
https://braincanada.ca/funded-grants/development-of-genetic-screening-platforms-for-immune-evasion-in-glioblastomaIn 2023, over 3,000 Canadians were newly diagnosed as brain tumor, and around 2,500 succumbed to this disease. Project Overview In 2023, over 3,000 Canadians were newly diagnosed as brain tumor, and around 2,500 succumbed to this disease. Despite strenuous efforts to fight against this serious...
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Development of novel oligonucleotide delivery modalities for Huntington disease
https://braincanada.ca/funded-grants/development-of-novel-oligonucleotide-delivery-modalities-for-huntington-diseaseHuntington disease (HD) is an inherited neurodegenerative disease that affects approximately 1 in 7500 individuals in the Western world. Project Overview Huntington disease (HD) is an inherited neurodegenerative disease that affects approximately 1 in 7500 individuals in the Western world. The...
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Developmental origins of stress and self-regulation and implications for interventions to improve childhood behavior
https://braincanada.ca/funded-grants/developmental-origins-of-stress-and-self-regulation-and-implications-for-interventions-to-improve-childhood-behaviorDr. Neuenschwander’s research aims to explore how exposure to stress during pregnancy affects children’s development, specifically in relation to children whose mothers were depressed and/or on antidepressants during pregnancy Project Overview Dr. Neuenschwander’s research aims to explore how...
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