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Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). Project Overview Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43...

Amyotrophic lateral sclerosis (ALS) is a nervous system disease that affects nerve cells (motor neurons) connecting muscle with the brain and spinal cord. Project Overview Amyotrophic lateral sclerosis (ALS) is a nervous system disease that affects nerve cells (motor neurons) connecting muscle with...

Attention Deficit Hyperactivity Disorder (ADHD) is the most common brain-related condition in children leading to challenges with attention and impulse control. As a result, children often struggle to stay focused or stop themselves from acting impulsively. Project Overview Attention Deficit...

We discovered that approximately one fifth of people with the deadly brain tumour glioblastoma show age-related genetic changes in their blood cells called ‘clonal hematopoiesis’, or CHIP. Project Overview We discovered that approximately one fifth of people with the deadly brain tumour...

RNA is a mobile form of genetic information that is made from our DNA and its complex regulation is extremely important to the proper functioning of our cells. Project Overview RNA is a mobile form of genetic information that is made from our DNA and its complex regulation is extremely important to...

Astrocytes are a major type of cells that react to brain activity, injuries and diseases to help support optimal brain functions. Project Overview Astrocytes are a major type of cells that react to brain activity, injuries and diseases to help support optimal brain functions. It is increasingly...

Partners and Donors Alzheimer Society of Canada

Imagine a neurosurgeon using light or sound to manipulate specific cells in your brain and restore your brain health. Instead of implanting electrodes and buzzing broader areas of your brain to help relieve symptoms of Parkinson’s disease, for example, a neurosurgeon would use gene therapy to...

When brain cells are injured during Alzheimer’s disease, those cells may either die or become too electrically excitable. Project Overview When brain cells are injured during Alzheimer’s disease, those cells may either die or become too electrically excitable. This study’s objective is to design...

We propose to develop chemically defined synthetic extracellular matrices to support neural cells in longterm stable cell culture. Project Overview We propose to develop chemically defined synthetic extracellular matrices to support neural cells in longterm stable cell culture. Human induced...