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Epigenetic mechanisms underlying dendritic atrophy in ALS
https://braincanada.ca/funded-grants/epigenetic-mechanisms-underlying-dendritic-atrophy-in-alsMotor neurons are made up of three distinct regions. The top of the neuron is composed of branches like a tree called dendrites that receive information to transmit. Project Overview Motor neurons are made up of three distinct regions. The top of the neuron is composed of branches like a tree...
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Epigenetics and mental health: the Canadian neuroepigenetics network
https://braincanada.ca/funded-grants/epigenetics-and-mental-health-the-canadian-neuroepigenetics-networkPsychiatry, like all areas of medicine and biology, has long considered the origins of individual differences. Project Overview Psychiatry, like all areas of medicine and biology, has long considered the origins of individual differences. This issue ultimately produced a nature vs nurture schism...
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Epitranscriptomic regulation of sleep, neurodegeneration, and longevity
https://braincanada.ca/funded-grants/epitranscriptomic-regulation-of-sleep-neurodegeneration-and-longevityThis research proposal investigates how a chemical modification called N6-methyladenosine (m6A) on messenger RNA influences brain health, specifically focusing on its role in sleep regulation, learning and memory, and neurodegenerative diseases such as Alzheimer’s. This research proposal...
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Establishing protein signatures of MRI-detected vascular brain injury in circulating endothelial-derived extracellularvesicles in Alzheimer’s disease
https://braincanada.ca/funded-grants/establishing-protein-signatures-of-mri-detected-vascular-brain-injury-in-circulating-endothelial-derived-extracellularvesicles-in-alzheimer-s-diseaseAge-related dementias are reaching epidemic levels, affecting over 600,000 Canadians. Project Overview Age-related dementias are reaching epidemic levels, affecting over 600,000 Canadians. The most common cause of age-related dementia is Alzheimer’s disease (AD). The defining pathology of AD is the...
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EthoLab: A platform for neurophysiological studies of natural behavior
https://braincanada.ca/funded-grants/etholab-a-platform-for-neurophysiological-studies-of-natural-behaviorSystems neuroscience owes much of its success to an empirical tradition of using simplified laboratory settings that carefully control sensory stimuli, motor responses, or other task-relevant variables in order to identify the neural mechanisms underlying different behavioral functions. Project...
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Evaluating an AI-Driven Mental Health App (LifeLine) in Northern Communities: A Randomized Controlled Trial
https://braincanada.ca/funded-grants/evaluating-an-ai-driven-mental-health-app-lifeline-in-northern-communities-a-randomized-controlled-trialMany people in northern and Indigenous communities in Saskatchewan face challenges in accessing mental health support due to distance, limited services, and long wait times. Project Overview Many people in northern and Indigenous communities in Saskatchewan face challenges in accessing mental...
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Evaluating an innovative e-mental health solution to support youth with mental health disorders in Northwestern Ontario
https://braincanada.ca/funded-grants/evaluating-an-innovative-e-mental-health-solution-to-support-youth-with-mental-health-disorders-in-northwestern-ontarioMany youth suffer from mental health-related brain disorders which can have devastating consequences Effective treatment is desperately needed. Project Overview Many youth suffer from mental health-related brain disorders which can have devastating consequences Effective treatment is desperately...
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Evaluating community-based exercise and rehabilitation for physical and personal achievement among people living with chronic neurological conditions
https://braincanada.ca/funded-grants/evaluating-community-based-exercise-and-rehabilitation-for-physical-and-personal-achievement-among-people-living-with-chronic-neurological-conditionsExercise and rehabilitation can help people with neurological conditions to improve physical function even years after a diagnosis. Yet, after hospital discharge, there are few available services for people with neurological conditions. Project Overview Exercise and rehabilitation can help people...
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Evaluating DLK activity in brain samples from Huntington’s disease patients
https://braincanada.ca/funded-grants/evaluating-dlk-activity-in-brain-samples-from-huntington-s-disease-patients"Background:Within the realm of neurodegenerative diseases, there is still a lack of effective disease-modifying treatments. Huntington’s Disease (HD) is no less immune to this issue, with only symptomatic treatment options being available for patients." Project Overview “Background:Within the...
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Evaluating the histone variant macroH2A1.1 as a master regulator of PARP1-Sirt1 balance in Alzheimer’s disease
https://braincanada.ca/funded-grants/evaluating-the-histone-variant-macroh2a1-1-as-a-master-regulator-of-parp1-sirt1-balance-in-alzheimer-s-diseaseAlzheimer’s Disease (AD) is characterized by memory decline and neuronal pathology, including amyloid β (Aβ)plaques and oxidative stress. Project Overview Alzheimer’s Disease (AD) is characterized by memory decline and neuronal pathology, including amyloid β (Aβ)plaques and oxidative stress. These...