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Investigating the molecular chaperone DNAJA2 as an inhibitor of tau aggregate pathology in Alzheimer’s
https://braincanada.ca/funded-grants/investigating-the-molecular-chaperone-dnaja2-as-an-inhibitor-of-tau-aggregate-pathology-in-alzheimer-sAlzheimer’s Disease is a progressive and fatal disease that currently afflicts up to 400,000 Canadians over the age of 65. Project Overview Alzheimer’s Disease is a progressive and fatal disease that currently afflicts up to 400,000 Canadians over the age of 65. One key observation about this...
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Investigating the Neurodevelopmental Trajectory of Emotional Face Processing in Autism Spectrum Disorder
https://braincanada.ca/funded-grants/investigating-the-neurodevelopmental-trajectory-of-emotional-face-processing-in-autism-spectrum-disorderAn understanding of emotional information from faces is critical for successful social interactions. Project Overview An understanding of emotional information from faces is critical for successful social interactions. A key component of ASD is poor social functioning. Deficits and dysfunction in...
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Investigating the neuronal function of a novel HNRNPA1 variant
https://braincanada.ca/funded-grants/investigating-the-neuronal-function-of-a-novel-hnrnpa1-variantWhile significant efforts have been made worldwide, the development of an effective therapy to significantly slow or halt amyotrophic lateral sclerosis (ALS) progression has remained elusive. Project Overview While significant efforts have been made worldwide, the development of an effective...
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Investigating the optimal reactive balance training intensity in chronic stroke patients
https://braincanada.ca/funded-grants/investigating-the-optimal-reactive-balance-training-intensity-in-chronic-stroke-patientsThis project will determine the optimal intensity of reactive balance training (RBT) for people with chronic stroke. Project Overview This project will determine the optimal intensity of reactive balance training (RBT) for people with chronic stroke. More specifically, we will find the intensity...
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Investigating the relationship between vascular risk factors and cognitive impairment in Canadian women from ethnically diverse groups
https://braincanada.ca/funded-grants/investigating-the-relationship-between-vascular-risk-factors-and-cognitive-impairment-in-canadian-women-from-ethnically-diverse-groupsTo obtain a more inclusive understanding of vascular contributions to cognitive impairment and dementia (VCID) in women, we will investigate the relationship between vascular health and cognition in women belonging to Canada’s three largest ethnic groups (South Asian, Chinese, and White). Project...
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Investigating the role of L-glucose as a therapy and [18F]fluoro-deoxy-L-glucose as a diagnostic for glioblastoma
https://braincanada.ca/funded-grants/investigating-the-role-of-l-glucose-as-a-therapy-and-18f-fluoro-deoxy-l-glucose-as-a-diagnostic-for-glioblastomaUsing the mirror image of body’s main sugar glucose (so-called L-glucose), we plan to hijack the sugar addiction of glioblastoma (GBM) as a therapeutic target. Project Overview Using the mirror image of body’s main sugar glucose (so-called L-glucose), we plan to hijack the sugar addiction of...
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Investigating the role of microglia in brain disorders, by high-throughput single-cell screening of disease-associated genes in human immuno-competent brain avatars
https://braincanada.ca/funded-grants/investigating-the-role-of-microglia-in-brain-disorders-by-high-throughput-single-cell-screening-of-disease-associated-genes-in-human-immuno-competent-brain-avatarsMost brain disorders remain incurable, whether they begin during early development, as seen in Autism, or seem acquired over time, as observed in Alzheimer’s disease. Project Overview Most brain disorders remain incurable, whether they begin during early development, as seen in Autism, or seem...
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Investigating the role of mutations in CHCHD10 using ALS cell and zebrafish genetic models
https://braincanada.ca/funded-grants/investigating-the-role-of-mutations-in-chchd10-using-als-cell-and-zebrafish-genetic-modelsCHCHD10 is a nuclear encoded mitochondrial protein of the twin Cx9C family whose cellular function remains to be fully understood. Project Overview CHCHD10 is a nuclear encoded mitochondrial protein of the twin Cx9C family whose cellular function remains to be fully understood. Several dominantly...
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Investigating the role of outer radial glia in autism using human pluripotent stem cells-derived 2D neural cultures and 3D brain organoids
https://braincanada.ca/funded-grants/investigating-the-role-of-outer-radial-glia-in-autism-using-human-pluripotent-stem-cells-derived-2d-neural-cultures-and-3d-brain-organoidsThe extraordinary size and folded shape of the human brain makes us the smartest animal on earth Project Overview The extraordinary size and folded shape of the human brain makes us the smartest animal on earth. However, it also means many diseases that harm the human brain disrupt cells and...
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Investigating the role of TDP-43 in DNA Replication: Implications for ALS Pathogenesis
https://braincanada.ca/funded-grants/investigating-the-role-of-tdp-43-in-dna-replication-implications-for-als-pathogenesisCells are constantly under stress due to several environmental and internal factors. Project Overview Cells are constantly under stress due to several environmental and internal factors. Accumulating stress over a period as seen in aging and neurodegenerative diseases like Amyotrophic Lateral...
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