Search

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the human motor system, leading to muscle weakness and ultimately paralysis. Project Overview Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the human motor system, leading to muscle...

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes muscle weakness and paralysis, partly due to the buildup of protein aggregates in nerve cells. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes muscle weakness and...

While most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1 (SPTLC1) arise in children. Project Overview While most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1...

Over 600,000 Canadians currently live with different types of dementia, and more than 76,000 new dementia cases are diagnosed each year. Project Overview Over 600,000 Canadians currently live with different types of dementia, and more than 76,000 new dementia cases are diagnosed each year. In over...

Rett syndrome is a severe neurological disorder that is caused by genetic mutations in the MECP2 gene. Project Overview Rett syndrome is a severe neurological disorder that is caused by genetic mutations in the MECP2 gene. The disorder almost exclusively affects females, presents in childhood and...

Scientists have long wondered what the contribution of environment is to ALS and in recent years the idea that a combination of genetic susceptibility and environmental triggers has taken shape. Project Overview Scientists have long wondered what the contribution of environment is to ALS and in...

The common end stage pathology of neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) is neuronal death. Project Overview The common end stage pathology of neurodegenerative diseases including Alzheimer’s disease (AD),...

In recent years, it was discovered that a microscopic worm called C. elegans could mimic some of the aspects of human ALS when they were engineered to have abnormal (mutant) genes that cause the disease. Project Overview In recent years, it was discovered that a microscopic worm called C. elegans...

Brain Canada and The ALS Society of Canada (ALS Canada) are proud to announce the recipients of the 2025 ALS Canada–Brain Canada Clinical Research Fellowship and Trainee Awards. Brain Canada and Diabetes Canada are pleased to announce funding for two research projects at the intersection of...

Dr. Christopher E. Pearson (left) and Dr. Ekaterina Rogaeva Controlling a DNA repeat expansion may indicate a path for future treatment "The best thing about being a scientist in this field is the people we work with, and the families we work for." Dr. Christopher E. Pearson Dr. Christopher E....