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Mapping the cellular origins of circuit vulnerability in neurodevelopmental disorders
https://braincanada.ca/funded-grants/mapping-the-cellular-origins-of-circuit-vulnerability-in-neurodevelopmental-disordersThe brain is an incredibly complex organ. Much of the brain’s complexity may be attributed to the circuitry that resides within. Project Overview The brain is an incredibly complex organ. Much of the brain’s complexity may be attributed to the circuitry that resides within. Synaptic connections are...
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Maternal care and child neurodevelopment: A longitudinal gene x environment analysis of socio-emotional development with an integrated approach
https://braincanada.ca/funded-grants/maternal-care-and-child-neurodevelopment-a-longitudinal-gene-x-environment-analysis-of-socio-emotional-development-with-an-integrated-approachMaternal depression, particularly during pregnancy, has been well established as a risk factor for child socio-emotional problems. Project Overview Maternal depression, particularly during pregnancy, has been well established as a risk factor for child socio-emotional problems. However, the impact...
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Measuring and Improving the Quality of Community-Based Dementia Care
https://braincanada.ca/funded-grants/measuring-and-improving-the-quality-of-community-based-dementia-careThere are an increasing number of people living with dementia. Project Overview There are an increasing number of people living with dementia. Improving and maintaining quality of life is rated as the highest priority for people living with dementia and their caregivers. While many factors...
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Measuring Neuroplasticity Outcomes of Theta Burst Stimulation in Depression Using Advanced PET Imaging
https://braincanada.ca/funded-grants/measuring-neuroplasticity-outcomes-of-theta-burst-stimulation-in-depression-using-advanced-pet-imagingIn Canada, 1 in 20 people live with depression. While many treatment options exist, a significant number of individuals do not respond adequately to current therapies, highlighting the urgent need for more effective solutions. One effective alternative to medication is theta burst stimulation (TBS)....
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Mechanisms of Cognitive Impairment in Children Treated for Brain Tumors
https://braincanada.ca/funded-grants/mechanisms-of-cognitive-impairment-in-children-treated-for-brain-tumorsIn developed countries, brain tumors are the leading cause of disability and death among children. Project Overview In developed countries, brain tumors are the leading cause of disability and death among children. Treatment advances have improved survival rates, but survival comes at a cost for...
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Mechanisms of delayed death in stroke
https://braincanada.ca/funded-grants/mechanisms-of-delayed-death-in-strokeStroke is a major cause of death and disability. At present, there are no clear and effective therapies to aid the majority of patients who suffer stroke. Project Overview Stroke is a major cause of death and disability. At present, there are no clear and effective therapies to aid the majority of...
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Mechanisms of focused ultRasound mEdiated BrAin cLeAniNg Coupled with enhanced mEchanosensation (REBALANCE)
https://braincanada.ca/funded-grants/mechanisms-of-focused-ultrasound-mediated-brain-cleaning-coupled-with-enhanced-mechanosensation-rebalanceFocused ultrasound (FUS) is a non-invasive, ground-breaking technique suggested for the treatment of Alzheimer’s disease (AD). Project Overview Focused ultrasound (FUS) is a non-invasive, ground-breaking technique suggested for the treatment of Alzheimer’s disease (AD). The partners of the...
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Mechanisms of glutamatergic neuronal dysfunction in genetic models of ALS
https://braincanada.ca/funded-grants/mechanisms-of-glutamatergic-neuronal-dysfunction-in-genetic-models-of-alsThis project will focus on comprehensively studying impaired transmission of signals (from the brain) at the location where neurons and muscles meet, called the neuromuscular junction. Project Overview This project will focus on comprehensively studying impaired transmission of signals (from the...
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Mechanisms of in vitro synaptic transmission of mis-folded human SOD1
https://braincanada.ca/funded-grants/mechanisms-of-in-vitro-synaptic-transmission-of-mis-folded-human-sod1The process by which ALS spreads throughout the body remains a mystery, but Dr. Neil Cashman has spent decades looking at how abnormal changes in shape (scientifically called misfolding) of crucial proteins (the substances that do life processes) in our cells might propagate disease from one cell to...
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Mechanisms of response and resistance to Olaparib and Durvalumab in treatment of glioblastomas and IDH-mutated astrocytomas
https://braincanada.ca/funded-grants/mechanisms-of-response-and-resistance-to-olaparib-and-durvalumab-in-treatment-of-glioblastomas-and-idh-mutated-astrocytomasGlioblastoma multiforme and high grade astrocytomas are aggressive brain tumors that are difficult to treat. Project Overview Glioblastoma multiforme and high grade astrocytomas are aggressive brain tumors that are difficult to treat. These tumors have genetic changes that affect their ability to...