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Modulating attentional circuitry in the anterior cingulate cortex using adaptive intracranial stimulation
https://braincanada.ca/funded-grants/modulating-attentional-circuitry-in-the-anterior-cingulate-cortex-using-adaptive-intracranial-stimulationAttention is an incompletely understood, complex process that requires precise coordination of brain rhythms within the anterior cingulate cortex (ACC). Project Overview Attention is an incompletely understood, complex process that requires precise coordination of brain rhythms within the anterior...
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Modulating consciousness during anesthesia through a non-pharmacological approach
https://braincanada.ca/funded-grants/modulating-consciousness-during-anesthesia-through-a-non-pharmacological-approachSlow oscillations (SOs) measured using electroencephalography (EEG) are a common feature of states with little to no conscious experience, such as coma, sleep, and anesthesia. Project Overview Slow oscillations (SOs) measured using electroencephalography (EEG) are a common feature of states with...
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Modulating memory circuits: focal DBS treatments to improve medial temporal lobe function
https://braincanada.ca/funded-grants/modulating-memory-circuits-focal-dbs-treatments-to-improve-medial-temporal-lobe-functionTwo diseases that show very different trajectories have nevertheless led researchers to identify dysfunction in a common brain network. Project Overview Two diseases that show very different trajectories have nevertheless led researchers to identify dysfunction in a common brain network. The...
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Modulating the ALS-associated C9orf72 repeat expansion in a murine model for therapeutic benefit
https://braincanada.ca/funded-grants/modulating-the-als-associated-c9orf72-repeat-expansion-in-a-murine-model-for-therapeutic-benefitMutations in a gene called C9ORF72 are the most common genetic cause of ALS. These mutations are unique in that unlike most other ALS-linked genes, where there is often a mistake in a single piece of DNA, C9ORF72 mutations involve a section of DNA that is abnormally repeated hundreds or even...
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Molecular and behavioural assessment of a potential fetal Cannabis spectrum disorder in the rat
https://braincanada.ca/funded-grants/molecular-and-behavioural-assessment-of-a-potential-fetal-cannabis-spectrum-disorder-in-the-ratCanada recently became the first G7 nation to legalize Cannabis for medicinal and recreational use. Project Overview Canada recently became the first G7 nation to legalize Cannabis for medicinal and recreational use. There is a recent and growing false belief that Cannabis can reduce nausea during...
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Molecular characterization of transcriptional repressor capicua in GBM
https://braincanada.ca/funded-grants/molecular-characterization-of-transcriptional-repressor-capicua-in-gbmMalignant gliomas, including oligodendrogliomas (OD) and glioblastomas (GBM), are currently incurable brain tumours with few effective treatment options. Project Overview Malignant gliomas, including oligodendrogliomas (OD) and glioblastomas (GBM), are currently incurable brain tumours with few...
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Molecular heterogeneity drives the clinical behaviour of childhood medulloblastoma
https://braincanada.ca/funded-grants/molecular-heterogeneity-drives-the-clinical-behaviour-of-childhood-medulloblastomaBrain cancer is the most common type of solid cancer in children in Canada, and medulloblastoma is the most common malignant brain cancer of childhood. Project Overview Brain cancer is the most common type of solid cancer in children in Canada, and medulloblastoma is the most common malignant brain...
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Molecular origins of childhood brain cancer
https://braincanada.ca/funded-grants/molecular-origins-of-childhood-brain-cancerPediatric high-grade gliomas are incurable brain cancers. Project Overview Pediatric high-grade gliomas are incurable brain cancers. Sequencing the tumor specimens has shown that most cases do not have obvious mutations that are known to cause cancer. It is therefore not known what causes, or...
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Molecular processes underlying neuromuscular junction denervation in humans with ALS
https://braincanada.ca/funded-grants/molecular-processes-underlying-neuromuscular-junction-denervation-in-humans-with-alsAmyotrophic lateral sclerosis (ALS) is marked by dysfunction and degeneration of neuromuscular junctions (NMJ). Project Overview Amyotrophic lateral sclerosis (ALS) is marked by dysfunction and degeneration of neuromuscular junctions (NMJ). This can be one of the earliest pathological processes...
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Molecular regulators of extracellular matrix remodeling during Amyotrophic Lateral Sclerosis
https://braincanada.ca/funded-grants/molecular-regulators-of-extracellular-matrix-remodeling-during-amyotrophic-lateral-sclerosisAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by the loss of motor neurons and the atrophy of muscles. Project Overview Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by the loss of motor neurons and the atrophy of...