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Synaptic plasticity is the process where the strength of connections between nerve cells is altered by experience. Project Overview Synaptic plasticity is the process where the strength of connections between nerve cells is altered by experience. It is widely believed that synaptic plasticity is...

Challenge: ALS (amyotrophic lateral sclerosis) is an incurable and invariably fatal motor neuron (MN) disease. Project Overview Challenge: ALS (amyotrophic lateral sclerosis) is an incurable and invariably fatal motor neuron (MN) disease. Our challenge is to develop a biologic-therapy that slows,...

Mutations in the SOD1 gene, leading to the misfolding and toxic aggregation of SOD1 protein, are the second leading cause of Familial Amyotrophic Lateral Sclerosis (FALS-SOD1) and emerging literature has detected misfolded SOD1 (mSOD1) in the cerebrospinal fluid (CSF) and post-mortem tissue of...

As our brains age, they become vulnerable to diseases such as Alzheimer’s disease which can cause dementia. Project Overview As our brains age, they become vulnerable to diseases such as Alzheimer’s disease which can cause dementia. Dementia is defined as cognitive (i.e., thinking) problems that...

In Alzheimer s disease (AD), critical synaptic connections between neurons disintegrate and cells die. Project Overview In Alzheimer s disease (AD), critical synaptic connections between neurons disintegrate and cells die. The brains of individuals with AD accumulate plaques of a protein fragment...

“There is a whole ecosystem within the central nervous system. This research provides a direct link as to what could really be going on when neurons are overactivated. If we can figure out the basis of that, then we can target that process with therapeutics.” – Dr. Janice Robertson One of the first...

Over 64% of older adults without neurocognitive disorders report forgetting the names of objects when speaking. Project Overview Over 64% of older adults without neurocognitive disorders report forgetting the names of objects when speaking. These difficulties are commonly dismissed as typical...

Neuropathic pain is a chronic pain disorder resulting from damage to the nerves. Project Overview Neuropathic pain is a chronic pain disorder resulting from damage to the nerves.  It may be due to cancer, diabetes or conditions like fibromyalgia. Neuropathic pain is often eased by antidepressant or...

In Alzheimer’s disease (AD), the accumulation of toxic Tau protein in neurons leads to the formation of neurofbillary tangles, cell death, and cognitive impairments. Project Overview In Alzheimer’s disease (AD), the accumulation of toxic Tau protein in neurons leads to the formation of...

For this project Dr. Sanjay Kalra and his team aims to improve on current techniques to use magnetic resonance imaging (MRI) as a readily available way to examine if a potential new treatment is working to slow down progression of ALS. Project Overview For this project Dr. Sanjay Kalra and his team...