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Road to Mental Readiness for Families and other Supportive Relationships
https://braincanada.ca/funded-grants/road-to-mental-readiness-for-families-and-other-supportive-relationshipsFirst responders, whose jobs commit them to persistent, repeated exposure to potentially triggering incidents, are at ongoing risk of developing mental health problems Project Overview First responders, whose jobs commit them to persistent, repeated exposure to potentially triggering incidents, are...
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Roche Canada invests $2+ million in Canadian Prospective Cohort Study to Understand Progression in Multiple Sclerosis (CanProCo)
https://braincanada.ca/about/news-updates/roche-canada-invests-2-million-in-canadian-prospective-cohort-study-to-understand-progression-in-multiple-sclerosis-canprocoToronto, ON – April 3, 2019 – The Multiple Sclerosis Society of Canada, Brain Canada Foundation, and Biogen Canada are pleased to announce the addition of Hoffmann-La Roche Limited (Roche Canada) and its contribution of $2.125 million to the Canadian Prospective Cohort Study to Understand...
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Role of ATF4 and P53 family transcription factors in the regulation of neuronal cell death
https://braincanada.ca/funded-grants/role-of-atf4-and-p53-family-transcription-factors-in-the-regulation-of-neuronal-cell-deathStroke is a leading cause of adult long term disability and the third leading cause of death in industrialized countries. Project Overview Stroke is a leading cause of adult long term disability and the third leading cause of death in industrialized countries. Brain cell death following stroke...
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Role of microglia-derived factors in glial scar formation and axonal regeneration failure after spinal cord injury
https://braincanada.ca/funded-grants/role-of-microglia-derived-factors-in-glial-scar-formation-and-axonal-regeneration-failure-after-spinal-cord-injuryThe role of microglia in spinal cord injury (SCI) has remained obscure for decades. Project Overview The role of microglia in spinal cord injury (SCI) has remained obscure for decades. Microglia, the resident immune cells of the brain and spinal cord, were historically perceived as harmful to...
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Role of mitochondrial c-Src kinase in Alzheimer’s disease
https://braincanada.ca/funded-grants/role-of-mitochondrial-c-src-kinase-in-alzheimer-s-diseaseMitochondrial dysfunctions are observed before and during the progression of Alzheimer’s disease (AD). Project Overview Mitochondrial dysfunctions are observed before and during the progression of Alzheimer’s disease (AD). It is important to understand how the regulation of mitochondria is impaired...
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Role of neurofilament NFL depletion in TDP-43-mediated pathogenesis
https://braincanada.ca/funded-grants/role-of-neurofilament-nfl-depletion-in-tdp-43-mediated-pathogenesisThis proposal is based on our finding of substantial depletion of neurofilament synthesis in mouse models of ALS with abnormal accumulations of TDP-43, a hallmark of the disease. Project Overview his proposal is based on our finding of substantial depletion of neurofilament synthesis in mouse...
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Role of the gut microbiome-brain axis in sexual dimorphism of ALS
https://braincanada.ca/funded-grants/role-of-the-gut-microbiome-brain-axis-in-sexual-dimorphism-of-alsMales are twice as likely to develop ALS compared to females and the disease onset is also earlier in males than females. Project Overview Males are twice as likely to develop ALS compared to females and the disease onset is also earlier in males than females. However, the mechanisms underlying the...
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Role of YAP/Hippo and Wnt signaling in human gliomagenesis and glioma tumour-initiating cells
https://braincanada.ca/funded-grants/role-of-yap-hippo-and-wnt-signaling-in-human-gliomagenesis-and-glioma-tumour-initiating-cellsDevelopmental signaling pathways are known to play important roles in normal neural stem cell (NSC) dynamics and can significantly alter the development of gliomas, highly aggressive brain tumours that arise from NSC-like tumour-initiating cells (TIC). Project Overview Developmental signaling...
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Roundtable report
https://braincanada.ca/about/news-updates/roundtable-reportNeuroScience Canada, the Canadian Association for Neuroscience (CAN), the Canadian Neurological Sciences Federation (CNSF), the Canadian Brain and Nerve Health Coalition (CBANHC), and the Barbara Turnbull Foundation partnered with the Public Policy Forum to hold a series of roundtable sessions...
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Routine enfant TDAH Phase 2
https://braincanada.ca/funded-grants/routine-enfant-tdah-phase-2“La bonne intervention, au bon moment, pour le bon enfant”. Project Overview “La bonne intervention, au bon moment, pour le bon enfant”. Le bien-être et l’amélioration des capacités adaptatives des enfants ayant des troubles du neurodéveloppement nécessitent des interventions personnalisées dans le...