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Parent-therapist partnership to provide early, intensive exercise to enhance walking outcomes in children with perinatal stroke
https://braincanada.ca/funded-grants/parent-therapist-partnership-to-provide-early-intensive-exercise-to-enhance-walking-outcomes-in-children-with-perinatal-strokePerinatal (around birth) stroke is devastating, because the effects are life-long. Project Overview Perinatal (around birth) stroke is devastating, because the effects are life-long. Current treatments to improve walking are limited, and largely passive, such as stretching, bracing, botulinum toxin...
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Partners and Donors Alzheimer Society of Canada
https://braincanada.ca/funded-grants/partners-and-donors-alzheimer-society-of-canadaPartners and Donors Alzheimer Society of Canada Alzheimer’s disease is a common form of memory loss and confusion affecting older adults. Despite many years of study, we still don’t have a cure for this disease. Project Overview Alzheimer’s disease is a common form of memory loss and confusion...
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Pathogenic Mechanism of C9orf72 haploinsufficiency in ALS/FTLD: a road to therapeutic discovery
https://braincanada.ca/funded-grants/pathogenic-mechanism-of-c9orf72-haploinsufficiency-in-als-ftld-a-road-to-therapeutic-discoveryIn this Hudson project, the team led by Dr. Robertson will pursue a comprehensive understanding of the normal functions of C9ORF72 and provide a better determination of whether loss of these functions via mutation may cause or contribute to ALS. Project Overview In this Hudson project, the team led...
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Pathogenic mechanisms of C9ORF72 repeat expansion in ALS and development of therapeutics
https://braincanada.ca/funded-grants/pathogenic-mechanisms-of-c9orf72-repeat-expansion-in-als-and-development-of-therapeuticsDr. Patten started his research career as a PhD student at the University of Alberta under the supervision of Dr. Declan Ali in 2004. Project Overview Dr. Patten started his research career as a PhD student at the University of Alberta under the supervision of Dr. Declan Ali in 2004. There he...
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Patient-reported outcome measures for social robots in dementia care
https://braincanada.ca/funded-grants/patient-reported-outcome-measures-for-social-robots-in-dementia-careImproving independence and quality of life for persons living with dementia (PLWD) and their care partners can be realized by complementing human care with robotic assistive technologies. Project Overview Improving independence and quality of life for persons living with dementia (PLWD) and their...
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Peripheral immune signatures of neurodegeneration in isolated REM sleep behavior disorder: an MRI-neuroinflammation study
https://braincanada.ca/funded-grants/peripheral-immune-signatures-of-neurodegeneration-in-isolated-rem-sleep-behavior-disorder-an-mri-neuroinflammation-studyWhen we dream, our bodies are normally paralyzed so we don’t act out the dream. In isolated REM sleep behavior disorder (iRBD), that safety switch fails: people may talk, shout, punch, or kick during sleep. iRBD is important because most people with it will later develop a brain disease like...
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Personalized medicine for Bipolar disorder: clinical lithium response as a guide to mode of action and biomarker discovery using human neurons and biofluids
https://braincanada.ca/funded-grants/personalized-medicine-for-bipolar-disorder-clinical-lithium-response-as-a-guide-to-mode-of-action-and-biomarker-discovery-using-human-neurons-and-biofluidsBipolar Disorder (BD) is a chronic psychiatric illness, ranking in the top 10 causes of disability and mortality worldwide, due to suicide and cardiovascular death. Project Overview Bipolar Disorder (BD) is a chronic psychiatric illness, ranking in the top 10 causes of disability and mortality...
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PET imaging of Alzheimer’s-induced inflammation to monitor progression and therapy response using a novel fructose-based radiotracer
https://braincanada.ca/funded-grants/pet-imaging-of-alzheimer-s-induced-inflammation-to-monitor-progression-and-therapy-response-using-a-novel-fructose-based-radiotracerOne of the key processes driving Alzheimer’s Disease is inflammation in the brain, the severity of which may predict the severity of disease. Project Overview One of the key processes driving Alzheimer’s Disease is inflammation in the brain, the severity of which may predict the severity of...
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Pharmacological Inhibition of TRPM2 in Neuroinflammation & Infection Models
https://braincanada.ca/funded-grants/pharmacological-inhibition-of-trpm2-in-neuroinflammation-infection-modelsAlzheimer’s Disease (AD) is a neurodegenerative disorder that affects a growing population and poses a significant public health challenge. It is characterized by cognitive decline and memory loss, of which current therapies only manage symptoms or slow disease progression and does not treat the...
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Phenotyping of Alzheimer’s disease across imaging-defined stages of cerebral amyloid angiopathy
https://braincanada.ca/funded-grants/phenotyping-of-alzheimer-s-disease-across-imaging-defined-stages-of-cerebral-amyloid-angiopathyMixed dementia is the most common form of dementia. Project Overview Background: Mixed dementia is the most common form of dementia. It occurs when Alzheimer’s disease (AD) combines with vascular disease, affecting both the blood vessels and the immune function in our brain. As this happens, memory...
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