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Polytechnique Montréal researcher receives the 2022 Turnbull-Tator Award for their contributions to Spinal Cord Injury Research
https://braincanada.ca/about/news-updates/polytechnique-montréal-researcher-receives-the-2022-turnbull-tator-award-for-their-contributions-to-spinal-cord-injury-researchDr. Marco Bonizzato wins prestigious award for outstanding publication in Science Translational Medicine Both brain and spinal cord injuries have a significant impact on productivity, health, quality of life and well-being of affected individuals. Research is a catalyst for discoveries that can...
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Portable Low Field MRI for Application in Multiple Sclerosis
https://braincanada.ca/funded-grants/portable-low-field-mri-for-application-in-multiple-sclerosisMultiple Sclerosis (MS) is a disease that attacks the nerves in the brain, making it difficult for the brain to send signals to the rest of the body. MS symptoms are extremely variable, and can include difficulty walking, fatigue, pain, and cognitive issues such as problems with concentration,...
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Post-mortem human hippocampal neuroplasticity, cognition, and late-life physical activity: Importance of biological sex and cognitive health status
https://braincanada.ca/funded-grants/post-mortem-human-hippocampal-neuroplasticity-cognition-and-late-life-physical-activity-importance-of-biological-sex-and-cognitive-health-statusThe world population is rapidly aging; there is a real need for effective, personalized lifestyle recommendations for promoting healthy cognitive aging. Project Overview The world population is rapidly aging; there is a real need for effective, personalized lifestyle recommendations for promoting...
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Powering CNS Drug Discovery
https://braincanada.ca/about/news-updates/powering-cns-drug-discoveryNew Translational Platform to Accelerate Treatments for Brain and Spinal Cord Disorders Brain Canada is proud to announce the final award in its 2024 Platform Support Grant (PSG) program: A Translational Platform in CNS Drug Development, led by Pr. Philippe Sarret at the Université de Sherbrooke,...
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Pre-clinical drug discovery against hexanucleotide repeat-containing C9orf72 toxicity using Caenorhabditis elegans and patient-derived induced motor neurons
https://braincanada.ca/funded-grants/pre-clinical-drug-discovery-against-hexanucleotide-repeat-containing-c9orf72-toxicity-using-caenorhabditis-elegans-and-patient-derived-induced-motor-neuronsA few years ago, Dr. Parker and researchers in his lab genetically engineered worms that mimicked human ALS through motor neuron degeneration and paralysis. Project Overview A few years ago, Dr. Parker and researchers in his lab genetically engineered worms that mimicked human ALS through motor...
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Precision diagnosis and prognosis of primary and metastatic brain tumours using DNA methylation profiling in liquid biopsy
https://braincanada.ca/funded-grants/precision-diagnosis-and-prognosis-of-primary-and-metastatic-brain-tumours-using-dna-methylation-profiling-in-liquid-biopsyNeed for project: More sensitive molecular tools are needed in the field of neuro-oncology to enable early detection, more accurate diagnosis, and prediction of outcome for brain tumors. Project Overview Need for project: More sensitive molecular tools are needed in the field of neuro-oncology to...
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Precision in Space and Time: Brain State-Dependent Stimulation Using Real-Time EEG and TMS
https://braincanada.ca/funded-grants/precision-in-space-and-time-brain-state-dependent-stimulation-using-real-time-eeg-and-tmsThe goal of this project is to develop new principles to treat brain disease and investigate brain function using non-invasive neurostimulation, without the side-effects of drugs. Project Overview The goal of this project is to develop new principles to treat brain disease and investigate brain...
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Precision Metabolism: Deciphering and Targeting Metabolic Adaptations in Therapy-Resistant Recurrent Glioblastoma
https://braincanada.ca/funded-grants/precision-metabolism-deciphering-and-targeting-metabolic-adaptations-in-therapy-resistant-recurrent-glioblastomaGlioblastoma (GBM) is a common and deadly brain cancer in adults. Project Overview Glioblastoma (GBM) is a common and deadly brain cancer in adults. Doctors use strong medicine (chemotherapy) and special rays (radiation therapy) to treat it. However, 80-90% of patients see the cancer come back, and...
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Preclinical and clinical studies with withanolides: Therapeutic effects, molecular signatures and biomarkers
https://braincanada.ca/funded-grants/preclinical-and-clinical-studies-with-withanolides-therapeutic-effects-molecular-signatures-and-biomarkersOne of the hallmarks of ALS is the presence of abnormal clumps inside motor neurons that contain various substances which include, in the majority of cases, something called TAR DNA–binding protein 43 (TDP-43). Project Overview One of the hallmarks of ALS is the presence of abnormal clumps inside...
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Preclinical assessment of a small molecule to treat neurodegeneration and inhibit disability in multiple sclerosis
https://braincanada.ca/funded-grants/preclinical-assessment-of-a-small-molecule-to-treat-neurodegeneration-and-inhibit-disability-in-multiple-sclerosisCanada has one of the highest rates of MS in the world, with treatment costing an estimated $2 billion per year by 2031. Even with modern treatments, persons living with MS accumulate long-term neurological disability over time. Project Overview Canada has one of the highest rates of MS in the...
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