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No medications exist that can stop or even slow the progression for Alzheimer Disease (AD). Project Overview No medications exist that can stop or even slow the progression for Alzheimer Disease (AD). Several dramatic late stage clinical failures have heightened recognition that novel approaches...

Concussions frequently occur worldwide, with a subset of patients experiencing lasting symptoms impacting their quality of life. Project Overview Concussions frequently occur worldwide, with a subset of patients experiencing lasting symptoms impacting their quality of life. Sub-concussive injuries,...

Serious mental illnesses (SMIs) such as recurrent unipolar depression, psychotic or bipolar disorder have multi-factorial causes, resulting from interactions among biological, clinical and psychosocial factors, including, but not limited to, stress, early trauma, and the use of psychoactive drugs....

Dr.  Hutchison‘s training is in lifespan psychology and her research broadly focuses on children’s cognitive and social development. Project Overview Dr.  Hutchison‘s training is in lifespan psychology and her research broadly focuses on children’s cognitive and social development. her current...

Primary progressive aphasia (PPA) is a form of dementia which impairs the ability to understand spoken and written language but other cognitive skills (including memory) remain intact for several years after its onset. Project Overview Primary progressive aphasia (PPA) is a form of dementia which...

This project is studying a novel intervention in 250 older persons whose major depression has been successfully treated with an antidepressant medication: a combination of cognitive remediation (CR, consisting of memory and problem solving exercises) plus transcranial Direct Current Stimulation...

RNA medicines—short strands of nucleic acids that can turn genes “up” or “down”—have changed how we treat brain diseases. For example, nusinersen for spinal muscular atrophy and tofersen for ALS are given by spinal injection to reach the brain and spinal cord. These breakthroughs show that RNA drugs...

Progressive Supranuclear Palsy (PSP) is a deadly disease of the brain with no cure. Project Overview Progressive Supranuclear Palsy (PSP) is a deadly disease of the brain with no cure. By studying the brains of patients who have died scientists have discovered that PSP brains contain toxic deposits...

From left to right: Azrieli Future Leader in Canadian Brain Research Chantelle Sephton, ALS Society of Canada Vice President Research Dave Taylor, Brain Canada CEO Viviane Poupon, ALS Canada - Brain Canada Discovery Grant recipients Jasna Kriz and Alex Parker at the ALS Research Forum in Toronto in...

Rationale: Cortical hyperexcitability has been identified to be a potential driver of ALS pathology leading to excitotoxicity and degeneration of upper motor neurons (UMNs)in the primary motor cortex (M1) and the subsequent degeneration of lower motor neurons (LMNs) in the spinal cord. Project...