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Evaluation of the role of EMMPRIN and MMP-9 in extracellular matrix degradation during ALS
https://braincanada.ca/funded-grants/evaluation-of-the-role-of-emmprin-and-mmp-9-in-extracellular-matrix-degradation-during-alsAmyotrophic Lateral Sclerosis (ALS) is a fatal disease that progressively destroys motor neurons, leading to paralysis and death, with no current cure. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a fatal disease that progressively destroys motor neurons, leading to paralysis and death,...
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Examining the neurobiological substrates of antidepressant effects of psilocybin: a PET imaging study using SYNVEST1
https://braincanada.ca/funded-grants/examining-the-neurobiological-substrates-of-antidepressant-effects-of-psilocybin-a-pet-imaging-study-using-synvest1In Canada, over 1 million people have been diagnosed with bipolar disorder (BD) in their lifetime. Project Overview In Canada, over 1 million people have been diagnosed with bipolar disorder (BD) in their lifetime. BD is characterized by recurrent episodes of depression and (hypo)mania. Many people...
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Examining the role of KCC2 in maintaining the balance between excitation and inhibition in ALS
https://braincanada.ca/funded-grants/examining-the-role-of-kcc2-in-maintaining-the-balance-between-excitation-and-inhibition-in-alsEach muscle in the body receives electrical signals through motor neurons that will stimulate it to contract. Project Overview Each muscle in the body receives electrical signals through motor neurons that will stimulate it to contract. Other specialized neurons inhibit these signals, allowing...
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Examining vascular risk and menopausal age on women’s increased risk for AD
https://braincanada.ca/funded-grants/examining-vascular-risk-and-menopausal-age-on-women-s-increased-risk-for-adTwo-thirds of individuals suffering from Alzheimer’s disease are women. Project Overview Two-thirds of individuals suffering from Alzheimer’s disease are women. The reason for women’s increased risk of Alzheimer’s disease is unknown. Menopause occurs when a decline in a hormone called estrogen...
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Exercise as Medicine: How Exercise Affects the Brains of Men and Women Differently
https://braincanada.ca/about/news-updates/exercise-as-medicine-how-exercise-affects-the-brains-of-men-and-women-differentlyDr. Cindy Barha Including sex and gender considerations into the reseach we support is improving the way we design, implement, and scale up novel health interventions. A case in point is Dr. Cindy Barha, a researcher who received a 2017 Brain Canada – Alzheimer’s Association Research Fellowship,...
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Expanding CNDR as an Open Science, Multi-modal Data Platform
https://braincanada.ca/funded-grants/expanding-cndr-as-an-open-science-multi-modal-data-platformNeuromuscular diseases (NMDs) are rare conditions that affect nerves and muscles. Project Overview Neuromuscular diseases (NMDs) are rare conditions that affect nerves and muscles. These diseases can be complex and require significant healthcare resources, but because they are rare, there are many...
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Expanding Registry for Research
https://braincanada.ca/about/news-updates/expanding-registry-for-researchPHOTO: Brain Canada President & CEO Viviane Poupon and Canadian Neuromuscular Disease Registry Executive Director Victoria Hodgkinson in Calgary, Alberta on May 27, 2025. Brain Canada is investing in transformative research platforms across the country to accelerate neuroscience discovery and...
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Exploitation of a new pharmacological target for the development and validation of new anti-inflammatory drugs
https://braincanada.ca/funded-grants/exploitation-of-a-new-pharmacological-target-for-the-development-and-validation-of-new-anti-inflammatory-drugsNeuroinflammation has been implicated in a diverse array of degenerative conditions, ranging from Multiple Sclerosis to Alzheimer’s disease. Project Overview Neuroinflammation has been implicated in a diverse array of degenerative conditions, ranging from Multiple Sclerosis to Alzheimer’s ...
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Exploring a cellular mystery
https://braincanada.ca/about/news-updates/exploring-a-cellular-mysteryDr. Maria Vera Ugalde loves fundamental biology. As a biochemist at McGill University, she spends her days using advanced microscopy techniques to see into the intricate workings of our cells. Will this new way of looking at certain protective proteins better explain their role in ALS? Award:...
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Exploring a therapeutic approach to promote neuronal function for ALS
https://braincanada.ca/funded-grants/exploring-a-therapeutic-approach-to-promote-neuronal-function-for-alsAmyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating neurodegenerative diseases which have overlap in pathological features and the genetic basis. Project Overview Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating...