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Medulloblastoma (MB) is a brain cancer that affects children. Medulloblastoma (MB) is a brain cancer that affects children. Current treatment for MB leaves patients with debilitating brain issues. We found that aggressive MB have low activity of a process called nonsense mediated decay (NMD)....

Women have a higher lifetime risk of Alzheimer’s disease (AD), possibly due to female-specific factors like menopause and pregnancy history. Project Overview Women have a higher lifetime risk of Alzheimer’s disease (AD), possibly due to female-specific factors like menopause and pregnancy history....

TDP-43 is an essential DNA/RNA binding protein at the epicenter of Amyotrophic Lateral Sclerosis (ALS). Project Overview TDP-43 is an essential DNA/RNA binding protein at the epicenter of Amyotrophic Lateral Sclerosis (ALS). Nearly all cases of ALS present with TDP-43 pathology involving nuclear to...

We are working on an innovative project to improve speech therapy for children who have trouble speaking or understanding language. Project Overview We are working on an innovative project to improve speech therapy for children who have trouble speaking or understanding language. We’re using a type...

Depression is a common mental health condition that affects millions of Canadians. Project Overview Depression is a common mental health condition that affects millions of Canadians. While there are treatment options available, some patients do not respond to conventional antidepressants and...

Parkinson’s disease is a neurodegenerative movement disorder. Project Overview Parkinson’s disease is a neurodegenerative movement disorder. At the cellular level, one of the main features of Parkinson’s disease is the clumping of a protein called alpha-synuclein. The disease gets worse as this...

CanChild’s ‘F-words for Child Development’ offer a fresh way for everyone to look at health. Based on WHO concepts, they present a holistic, strengths-based, function-promoting, family-centred approach to child health. Project Overview CanChild’s ‘F-words for Child Development’ offer a fresh way...

hiPSC derived neurons The project A $1.5 million platform grant awarded by Brain Canada in 2015 in partnership with the Marigold Foundation, McGill University, the Quebec Pain Research Network, and the Réseau de médecine génétique appliquée, allowed Prinicpal Investigator Jack Puymirat and his team...

Multiple Sclerosis (MS) is a disease that affects the brain and spinal cord, leading to a gradual loss of nerve function. Canada—especially Saskatchewan—has the highest rates of MS in the world. Project Overview Multiple Sclerosis (MS) is a disease that affects the brain and spinal cord, leading to...