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Two-thirds of individuals suffering from Alzheimer’s disease are women. Project Overview Two-thirds of individuals suffering from Alzheimer’s disease are women. The reason for women’s increased risk of Alzheimer’s disease is unknown. Menopause occurs when a decline in a hormone called estrogen...

Dr. Cindy Barha Including sex and gender considerations into the reseach we support is improving the way we design, implement, and scale up novel health interventions. A case in point is Dr. Cindy Barha, a researcher who received a 2017 Brain Canada – Alzheimer’s Association Research Fellowship,...

Neuromuscular diseases (NMDs) are rare conditions that affect nerves and muscles. Project Overview Neuromuscular diseases (NMDs) are rare conditions that affect nerves and muscles. These diseases can be complex and require significant healthcare resources, but because they are rare, there are many...

PHOTO: Brain Canada President & CEO Viviane Poupon and Canadian Neuromuscular Disease Registry Executive Director Victoria Hodgkinson in Calgary, Alberta on May 27, 2025. Brain Canada is investing in transformative research platforms across the country to accelerate neuroscience discovery and...

Neuroinflammation has been implicated in a diverse array of degenerative conditions, ranging from Multiple Sclerosis  to  Alzheimer’s  disease. Project Overview Neuroinflammation has been implicated in a diverse array of degenerative conditions, ranging from Multiple Sclerosis  to  Alzheimer’s ...

Dr. Maria Vera Ugalde loves fundamental biology. As a biochemist at McGill University, she spends her days using advanced microscopy techniques to see into the intricate workings of our cells. Will this new way of looking at certain protective proteins better explain their role in ALS? Award:...

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating neurodegenerative diseases which have overlap in pathological features and the genetic basis. Project Overview Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating...

Medulloblastoma (MB) is a brain cancer that affects children. Medulloblastoma (MB) is a brain cancer that affects children. Current treatment for MB leaves patients with debilitating brain issues. We found that aggressive MB have low activity of a process called nonsense mediated decay (NMD)....

Women have a higher lifetime risk of Alzheimer’s disease (AD), possibly due to female-specific factors like menopause and pregnancy history. Project Overview Women have a higher lifetime risk of Alzheimer’s disease (AD), possibly due to female-specific factors like menopause and pregnancy history....

TDP-43 is an essential DNA/RNA binding protein at the epicenter of Amyotrophic Lateral Sclerosis (ALS). Project Overview TDP-43 is an essential DNA/RNA binding protein at the epicenter of Amyotrophic Lateral Sclerosis (ALS). Nearly all cases of ALS present with TDP-43 pathology involving nuclear to...