Search

The first genetic cause of ALS to be discovered (in 1993) encoded a mutation in protein called superoxide dismutase 1 (SOD1). Project Overview The first genetic cause of ALS to be discovered (in 1993) encoded a mutation in protein called superoxide dismutase 1 (SOD1). Decades later, it is largely...

Stroke is the sudden death of brain cells caused by insufficient blood supply to the brain. Parts of the brain that enable us to walk and talk are often damaged most by a stroke. Project Overview Stroke is the sudden death of brain cells caused by insufficient blood supply to the brain. Parts of...

Converging research efforts have recently identified five genes that are associated with familial Parkinson’s Disease (PD), a condition associated with severe motor dysfunction and loss of dopamine-producing cells in the brain. Project Overview Converging research efforts have recently identified...

Parkinson’s Disease (PD) is an age-associated movement disorders, mainly caused by the death of dopamine cells in the brain. Project Overview Parkinson’s Disease (PD) is an age-associated movement disorders, mainly caused by the death of dopamine cells in the brain. Over 90% of PD cases are...

Mitochondria are cellular components which provide the energy required by the brain. Any alteration of these small engines can lead to brain disorders, but their role in dementia remains poorly understood. Project Overview Mitochondria are cellular components which provide the energy required by...

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease in which the motor neurons degenerate, leading to symptoms of muscle weakness and progressive paralysis, resulting in the death of patients from respiratory failure. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a...

Attention is an incompletely understood, complex process that requires precise coordination of brain rhythms within the anterior cingulate cortex (ACC). Project Overview Attention is an incompletely understood, complex process that requires precise coordination of brain rhythms within the anterior...

Slow oscillations (SOs) measured using electroencephalography (EEG) are a common feature of states with little to no conscious experience, such as coma, sleep, and anesthesia. Project Overview Slow oscillations (SOs) measured using electroencephalography (EEG) are a common feature of states with...

Two diseases that show very different trajectories have nevertheless led researchers to identify dysfunction in a common brain network. Project Overview Two diseases that show very different trajectories have nevertheless led researchers to identify dysfunction in a common brain network. The...

Mutations in a gene called C9ORF72 are the most common genetic cause of ALS. These mutations are unique in that unlike most other ALS-linked genes, where there is often a mistake in a single piece of DNA, C9ORF72 mutations involve a section of DNA that is abnormally repeated hundreds or even...