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Focused ultrasound (FUS) is a non-invasive, ground-breaking technique suggested for the treatment of Alzheimer’s disease (AD). Project Overview Focused ultrasound (FUS) is a non-invasive, ground-breaking technique suggested for the treatment of Alzheimer’s disease (AD). The partners of the...

This project will focus on comprehensively studying impaired transmission of signals (from the brain) at the location where neurons and muscles meet, called the neuromuscular junction. Project Overview This project will focus on comprehensively studying impaired transmission of signals (from the...

The process by which ALS spreads throughout the body remains a mystery, but Dr. Neil Cashman has spent decades looking at how abnormal changes in shape (scientifically called misfolding) of crucial proteins (the substances that do life processes) in our cells might propagate disease from one cell to...

Glioblastoma multiforme and high grade astrocytomas are aggressive brain tumors that are difficult to treat. Project Overview Glioblastoma multiforme and high grade astrocytomas are aggressive brain tumors that are difficult to treat. These tumors have genetic changes that affect their ability to...

This project will focus on unique roles of FUS (an ALS gene/protein) at the junction where neurons connect, called the synapse. Project Overview This project will focus on unique roles of FUS (an ALS gene/protein) at the junction where neurons connect, called the synapse. Most of the work done on...

In Canada, one individual suffers a stroke every seven minutes. Project Overview In Canada, one individual suffers a stroke every seven minutes. Of those who survive, roughly 30% will have aphasia, a difficulty speaking with- or understanding others. Aphasia can have a significant negative impact...

Alzheimer’s disease is the most common cause of dementia and affects hundreds of thousands of Canadians. Both genetic and environmental factors contribute to its development, but recent research highlights the importance of the brain’s immune system—particularly a specialized immune cell type called...

Our research program is centered on investigating the important contributions of metabolism to brain health. Project Overview Our research program is centered on investigating the important contributions of metabolism to brain health. It is generally well-accepted that proper nutrition is a major...

Antoine is a graduate student at Université Laval, where he is testing whether a high-fat ketogenic diet can rewire energy metabolism in ALS, potentially slowing the disease by improving the health of our brain cell’s powerhouse – the mitochondria. Behind every promising researcher is someone who...

Twenty-six early-career scientists will each receive $100,000 to pursue bold high-risk ideas in brain and mental health research, from eating disorders to chronic pain to neurodegeneration. Twenty-six early-career scientists will each receive $100,000 to pursue bold high-risk, high-reward ideas in...