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Peripheral immune signatures of neurodegeneration in isolated REM sleep behavior disorder: an MRI-neuroinflammation study
https://braincanada.ca/funded-grants/peripheral-immune-signatures-of-neurodegeneration-in-isolated-rem-sleep-behavior-disorder-an-mri-neuroinflammation-studyWhen we dream, our bodies are normally paralyzed so we don’t act out the dream. In isolated REM sleep behavior disorder (iRBD), that safety switch fails: people may talk, shout, punch, or kick during sleep. iRBD is important because most people with it will later develop a brain disease like...
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Personalized medicine for Bipolar disorder: clinical lithium response as a guide to mode of action and biomarker discovery using human neurons and biofluids
https://braincanada.ca/funded-grants/personalized-medicine-for-bipolar-disorder-clinical-lithium-response-as-a-guide-to-mode-of-action-and-biomarker-discovery-using-human-neurons-and-biofluidsBipolar Disorder (BD) is a chronic psychiatric illness, ranking in the top 10 causes of disability and mortality worldwide, due to suicide and cardiovascular death. Project Overview Bipolar Disorder (BD) is a chronic psychiatric illness, ranking in the top 10 causes of disability and mortality...
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PET imaging of Alzheimer’s-induced inflammation to monitor progression and therapy response using a novel fructose-based radiotracer
https://braincanada.ca/funded-grants/pet-imaging-of-alzheimer-s-induced-inflammation-to-monitor-progression-and-therapy-response-using-a-novel-fructose-based-radiotracerOne of the key processes driving Alzheimer’s Disease is inflammation in the brain, the severity of which may predict the severity of disease. Project Overview One of the key processes driving Alzheimer’s Disease is inflammation in the brain, the severity of which may predict the severity of...
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Pharmacological Inhibition of TRPM2 in Neuroinflammation & Infection Models
https://braincanada.ca/funded-grants/pharmacological-inhibition-of-trpm2-in-neuroinflammation-infection-modelsAlzheimer’s Disease (AD) is a neurodegenerative disorder that affects a growing population and poses a significant public health challenge. It is characterized by cognitive decline and memory loss, of which current therapies only manage symptoms or slow disease progression and does not treat the...
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Phenotyping of Alzheimer’s disease across imaging-defined stages of cerebral amyloid angiopathy
https://braincanada.ca/funded-grants/phenotyping-of-alzheimer-s-disease-across-imaging-defined-stages-of-cerebral-amyloid-angiopathyMixed dementia is the most common form of dementia. Project Overview Background: Mixed dementia is the most common form of dementia. It occurs when Alzheimer’s disease (AD) combines with vascular disease, affecting both the blood vessels and the immune function in our brain. As this happens, memory...
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Physical fingerprints of single extracellular vesicles for liquid biopsy in brain cancer
https://braincanada.ca/funded-grants/physical-fingerprints-of-single-extracellular-vesicles-for-liquid-biopsy-in-brain-cancerNeed for project: Glioblastoma (GBM) is an incurable brain cancer that changes rapidly confounding standard diagnostic and therapeutic methods. Project Overview Need for project: Glioblastoma (GBM) is an incurable brain cancer that changes rapidly confounding standard diagnostic and therapeutic...
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Pictures of Resilience: A PAR Photovoice Mental Health Needs Assessment with Migrant Kalaalleq Youth Living in Copenhagen
https://braincanada.ca/funded-grants/pictures-of-resilience-a-par-photovoice-mental-health-needs-assessment-with-migrant-kalaalleq-youth-living-in-copenhagenThis project will be a participatory action research project launched in collaboration with the Greenlandic House of Copenhagen Project Overview This project will be a participatory action research project launched in collaboration with the Greenlandic House of Copenhagen, a heritage and cultural...
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Platform dedicated to finding better therapies for mobility impairment
https://braincanada.ca/about/news-updates/platform-dedicated-to-finding-better-therapies-for-mobility-impairmentBrain Canada is pleased to announce the awarding of a 2021 Platform Support Grant (PSG) to Dr. Vivian K. Mushahwar from the University of Alberta. Together with the University of Alberta, Brain Canada is awarding $3.14M to support the SMART Platform, a state-of-the-art platform to advance...
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Platform for Neurology Biomarker Innovation
https://braincanada.ca/funded-grants/platform-for-neurology-biomarker-innovationInnovative methods that enable brain-derived proteins to be measured in blood samples are transforming the field of neurology. For example, it is now possible to use a blood test to help diagnose Alzheimer’s Disease and to monitor treatment in Multiple Sclerosis. This project will establish The...
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Polygenic applications of aging to brain and cognitive reserve in multiple sclerosis
https://braincanada.ca/funded-grants/polygenic-applications-of-aging-to-brain-and-cognitive-reserve-in-multiple-sclerosisReserve is someone’s ability to tolerate age-related changes and disease-related insults to their brain without developing symptoms. Project Overview Reserve is someone’s ability to tolerate age-related changes and disease-related insults to their brain without developing symptoms. How reserve...