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Prototype NIR Ca2+ indicators into refined tools that can be applied for neuronal activity imaging in model organisms
https://braincanada.ca/funded-grants/prototype-nir-ca2-indicators-into-refined-tools-that-can-be-applied-for-neuronal-activity-imaging-in-model-organismsOne of the major challenges facing the BRAIN initiative is the development of technologies that will enable the recording of neural activity throughout the entire volume of a rodent brain. Project Overview One of the major challenges facing the BRAIN initiative is the development of technologies...
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Psychological health and wellness among medical doctors in Canada and the impact of the Wellness4MDs supportive text messaging program.
https://braincanada.ca/funded-grants/psychological-health-and-wellness-among-medical-doctors-in-canada-and-the-impact-of-the-wellness4mds-supportive-text-messaging-programThis project’s main aim is to create and test a daily text messaging program called Wellness4MDs to help doctors, medical trainees, and students in Canada deal with burnout, anxiety, and depression. Project Overview This project’s main aim is to create and test a daily text messaging program called...
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Pushing boundaries in medical imaging to explore new pathways for ALS treatment
https://braincanada.ca/about/news-updates/pushing-boundaries-in-medical-imaging-to-explore-new-pathways-for-als-treatment“The idea is to not only diagnose but also to help in developing targeted treatments.” – Dr. Freimut Juengling Neurological imaging has advanced by leaps and bounds in the past two decades. Researchers can now “see” details of biological processes at a level never previously imagined. But we still...
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Pushing the boundaries of autism research
https://braincanada.ca/about/news-updates/pushing-the-boundaries-of-autism-research -
Quantitative fluorescence spectroscopy of the central nervous system amylome
https://braincanada.ca/funded-grants/quantitative-fluorescence-spectroscopy-of-the-central-nervous-system-amylomeIt is generally acknowledged that accumulation of misfolded proteins (amyloid) in brains of Alzheimer’s disease patients is a key disease phenomenon. Project Overview It is generally acknowledged that accumulation of misfolded proteins (amyloid) in brains of Alzheimer’s disease patients is a key...
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Quantitative MRI as a biomarker of tumour resistance to radiation treatment in brain metastasis
https://braincanada.ca/funded-grants/quantitative-mri-as-a-biomarker-of-tumour-resistance-to-radiation-treatment-in-brain-metastasisBrain metastasis occurs in 20% to 40% of all cancer patients and impacts quality of life and survival. Stereotactic radiosurgery (SRS), which involves delivering high doses of radiation to the tumour, is the preferred treatment for these patients. Project Overview Brain metastasis occurs in 20% to...
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Quantitative PET/MR Imaging of Brain Derived Neurotrophic Factor (BDNF) / Tropomyosin Related Kinase B (TRKB) signaling in ALS – decoding a potential pathogenetic pathway
https://braincanada.ca/funded-grants/quantitative-pet-mr-imaging-of-brain-derived-neurotrophic-factor-bdnf-tropomyosin-related-kinase-b-trkb-signaling-in-als-decoding-a-potential-pathogenetic-pathwayBrain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions, via activation of its high affinity receptor, tropomysin related kinase B (TrkB). Project Overview Brain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions, via...
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Radiomics and machine learning based non-invasive biomarkers for prediction of peritumoral invasion in brain metastases
https://braincanada.ca/funded-grants/radiomics-and-machine-learning-based-non-invasive-biomarkers-for-prediction-of-peritumoral-invasion-in-brain-metastasesNeed for project: Treatment of brain metastases (BrM) includes a combination of surgery and radiation therapy (RT). Project Overview Need for project: Treatment of brain metastases (BrM) includes a combination of surgery and radiation therapy (RT). Recurrence after treatment is a problem that...
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Rational targeting of FUS and TDP-43 protein assemblies for diagnostics and treatment of ALS
https://braincanada.ca/funded-grants/rational-targeting-of-fus-and-tdp-43-protein-assemblies-for-diagnostics-and-treatment-of-alsThe project addresses a grand challenge in ALS, the integration of a multi-targeted and personalized approach to patients with a rational strategy focusing on a unifying pivotal mechanism of the disease. Project Overview The project addresses a grand challenge in ALS, the integration of a...
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RBC Disruptors – Rewiring the Brain
https://braincanada.ca/about/news-updates/rbc-disruptors-rewiring-the-brainTechnology is disrupting the brain. Dr. Murali Doraiswamy, a physician and brain scientist at Duke University highlighted that 8%-10% of people in North America show signs of a serious addiction to the Internet and gaming – on this special episode we turned our minds inward – Murali shares his...