Aperçu du projet

Restoring inhibitory control in the stressed amygdala: peroxisome proliferator-activated receptors as regulators of memory precision and engram sparsity in mice

Post-traumatic stress disorder (PTSD) affects about 8% of Canadian adults, causing intrusive memories and inappropriate fear responses that are often resistant to current treatments. This project will investigate how chronic social stress influences fear memory overgeneralization in mice, a key feature of PTSD. Researchers will study the molecular and neural mechanisms involved, focusing on endocannabinoid signaling and inflammation, which may contribute to stress-related changes in fear processing. The goal is to improve understanding of how the brain stores threat memories and to identify new strategies for more effective PTSD and anxiety treatments.

Chef d'équipe

Mohammed Sarikahya , The Hospital for Sick Children