Characterizing the effects of blocking TDP-43 SUMOylation during cellular stress and recovery using live-cell imaging
Aperçu du projet
A common feature in almost all ALS cases is the build up of a protein called TDP-43 in the brain and spinal cord. We have identified a process called « SUMOylation » that helps prevent the clumping of TDP-43. We created a mouse model where we disrupted SUMOylation and observed that these mice develop symptoms related to ALS. Using high resolution microscopy, we aim to visualize exactly how SUMOylation interacts with TDP-43 in real time. Ultimately, this study will give us a better understanding into the key pathways on how SUMOylation plays a protective role, which may help develop treatments for ALS.
Chef d'équipe
Jenny Zhang , University of Ottawa
Partenaire et Donateurs
Naomi Azrieli, François Blanc and Family