Control of mRNA translation in Microglia response to Alzheimer’s disease pathology
Aperçu du projet
Microglia are the brain’s immune cells, and their role is to protect the brain. Yet in Alzheimer’s disease, these cells are often found diseased as well. In a brain with Alzheimer’s disease, the microglia’s ability to provide instruction is defective. This study’s hypothesis is that restoring translation on microglia will restore their ability to restrain Alzheimer’s disease pathology. Many studies address microglia function by measuring cell instructions. This study will explore several experimental paradigms to examine the mechanisms and consequences of restoring translation in microglia responding to Alzheimer’s disease pathology. This research could open new treatment avenues to boost microglia’s protective roles.
Nahum Sonenberg , McGill University
Partenaire et Donateurs
Alzheimer Society of Canada