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Targeting the immune suppressive microenvironment in histone 3-mutant high-grade gliomas

Aperçu du projet

The immune system is responsible for protecting the body against diseases, but it can also play a role in tumor formation. By exploring the role of these cells in cancer, we can understand how they promote tumor progression. In this project, our goal is to modify the activity of a specific population of immune cells, called myeloid cells, which are abundant in high-grade pediatric brain tumors, to determine their involvement in tumor growth. We will also alter the signals that prevent white blood cells from destroying cancer cells. Our preliminary results are promising, and our studies could pave the way for clinical trials using immunotherapy to treat these devastating diseases in patients.

Chef d'équipe

Nada Jabado , Institut de recherche du centre universitaire de santé McGill

Partenaire et Donateurs

Cancer Research Society

Projet en cours

Targeting the immune suppressive microenvironment in histone 3-mutant high-grade gliomas

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Cancer

  • Disease Area

    Brain Cancer

  • Compétition

    CRS Operating Grants

  • Province

    Québec

  • Date de Début

    2024

  • Montant total du financement

    $130,000

  • Contribution Santé Canada

    $65,000