Répertoire des subventions financées

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Does psilocybin increase synaptic density in the brain in patients with mild cognitive impairment?

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Compétition

    Alzheimer Society Research Program (ASRP)

  • Province

    Ontario

  • Date de Début

    2024

  • Montant total du financement

    $100,000

  • Contribution Santé Canada

    $50,000

Aperçu du projet

Amnestic mild cognitive impairment (aMCI) is viewed as a precursor to Alzheimer’s Disease (AD) for which there are no effective treatments. Evidence suggests that psilocybin exerts its psychedelic, and possibly its clinical effects, through activating cellular serotonin receptors in the brain. Intriguingly, reduced serotonin receptor density in the brain is…

Projet en cours

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Genes involved in APP-mediated GLUT1 regulation

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Compétition

    Alzheimer Society Research Program (ASRP)

  • Province

    Québec

  • Date de Début

    2024

  • Montant total du financement

    $100,000

  • Contribution Santé Canada

    $50,000

Aperçu du projet

Alzheimer’s disease is the most common form of dementia. The brains of many of the patients are less well supplied with glucose (sugar), but not much research aims to understand why this happens. Further, a protein of central importance to Alzheimer’s disease is APP. My lab found that there may…

Projet en cours

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Targeting the microbiota-gut-brain axis with diet and exercise interventions in individuals with subjective cognitivedecline

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Compétition

    Alzheimer Society Research Program (ASRP)

  • Province

    Ontario

  • Date de Début

    2024

  • Montant total du financement

    $100,000

  • Contribution Santé Canada

    $50,000

Aperçu du projet

Individuals with or at increased risk of Alzheimer’s disease (AD) have an altered community of microbes(microbiome) within the intestinal tract. Through the production of inflammatory and neurotoxic metabolites, this microbial population may negatively contribute to cognitive decline and early dementia risk. Lifestyle interventions, such as diet and exercise, have been…

Projet en cours

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MicroRNA biomarkers: Using Tears to Assess Alzheimer’s Disease

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Compétition

    Alzheimer Society Research Program (ASRP)

  • Province

    British Columbia

  • Date de Début

    2024

  • Montant total du financement

    $10,000

  • Contribution Santé Canada

    $50,000

Aperçu du projet

Alzheimer’s disease (AD) is the most common form of dementia and 7th leading cause of death in North-America. It affects memory, thinking and behavior, thus causing major challenges to patients, families, society, and healthcare systems. Today, diagnosis requires expensive radioactive brain scans or spinal fluid markers obtained through harmful procedures.…

Projet en cours

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Evaluating the histone variant macroH2A1.1 as a master regulator of PARP1-Sirt1 balance in Alzheimer’s disease

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Compétition

    Alzheimer Society Research Program (ASRP)

  • Province

    Ontario

  • Date de Début

    2024

  • Montant total du financement

    $10,000

  • Contribution Santé Canada

    $50,000

Aperçu du projet

Alzheimer’s Disease (AD) is characterized by memory decline and neuronal pathology, including amyloid β (Aβ)plaques and oxidative stress. These markers are influenced by PARP1, which propagates cellular damage, and Sirt1, which protects against cellular damage. PARP1 becomes hyperactive in AD and inhibits Sirt1, thus propagating neuronal damage and memory decline.…

Projet en cours

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