Répertoire des subventions financées

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539 ésultat(s) trouvé(s)

Deepening our understanding of G3BP1 and its paralog G3BP2 to facilitate accurate therapeutic development for ALS/FTD

  • Type de programme

    Team grants

  • Disease Area

    ALS FR

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Subventions de découverte

  • Province

    Québec

  • Date de Début

    2023

  • Montant total du financement

    $125,000

  • Contribution Santé Canada

    $62,500

Aperçu du projet

While significant efforts have been made worldwide, the development of an effective therapy to significantly slow or halt ALS disease progression has remained elusive. This is due in part to our incomplete understanding of the molecular mechanisms and aberrant processes that lead to disease. TDP-43 (TAR DNA binding protein 43)…

The impact of ALS disease variants on regulation of heat shock protein life cycles – Implications for neuronal proteostasis

  • Type de programme

    Team grants

  • Disease Area

    ALS FR

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Subventions de découverte

  • Province

    Québec

  • Date de Début

    2023

  • Montant total du financement

    $125,000

  • Contribution Santé Canada

    $62,500

Aperçu du projet

The abnormal accumulation of misfolded proteins and aggregates is the hallmark of multiple forms of ALS and other neurodegenerative diseases. The toxicity of these aberrant proteins is compounded by deficiency in mechanisms regulating protein quality control and alterations they cause in the metabolism of mRNAs that sustain neuronal functionality. A…

Mechanisms of focused ultRasound mEdiated BrAin cLeAniNg Coupled with enhanced mEchanosensation (REBALANCE)

  • Type de programme

    Team grants

  • Disease Area

    Alzheimer’s

  • Compétition

    EU Joint Programme – Neurodegenerative Disease Research (JPND)

  • Province

    Ontario

  • Date de Début

    2023

  • Montant total du financement

    $333,000

  • Contribution Santé Canada

    $330,000

Aperçu du projet

Focused ultrasound (FUS) is a non-invasive, ground-breaking technique suggested for the treatment of Alzheimer’s disease (AD). The partners of the REBALANCE consortia have demonstrated therapeutic efficacy for FUS alone and FUS stimulation combined with microbubbles. At the cellular level, FUS promotes transient opening of the blood brain barrier (BBB) and…

F-words Foundations for families & service providers training program

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodevelopment

  • Compétition

    KBHN Strategic Investment Fund

  • Province

    Ontario

  • Date de Début

    2022

  • Montant total du financement

    $555,291

  • Contribution Santé Canada

    $277,631

Aperçu du projet

CanChild’s ‘F-words for Child Development’ offer a fresh way for everyone to look at health. Based on WHO concepts, they present a holistic, strengths-based, function-promoting, family-centred approach to child health. These ideas have captured the attention of families and service providers (SPs) worldwide. The uptake of the F-words, and requests…

Community implementation and evaluation of acceptance and commitment training (ACT) for family caregivers

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodevelopment

  • Compétition

    KBHN Strategic Investment Fund

  • Province

    Ontario

  • Date de Début

    2022

  • Montant total du financement

    $479,141

  • Contribution Santé Canada

    $239,571

Aperçu du projet

Family caregivers of people with neurodevelopmental disabilities (NDDs) often experience stress and mental health difficulties (e.g., anxiety, depression); however, there are few services to support their wellbeing. Acceptance and Commitment Training (ACT), which increases acceptance and mindfulness skills to help people cope, may be helpful to them. Our ACT-based intervention…