Répertoire des subventions financées

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Apolipoprotein receptor 2 in AD-related brain vessel dysfunction

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Compétition

    Alzheimer’s Association International Grant Program

  • Province

    Alberta

  • Date de Début

    2024

  • Montant total du financement

    $199,300

  • Contribution Santé Canada

    $81,500

Aperçu du projet

What is the role of apolipoprotein receptor 2, a protein found in the brain vessels, in Alzheimer's disease ? The brain vascular system is critical to supply the necessary energy and control the transport of molecules in and out of the brain. Failure of this system is seen early in…

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Examining vascular risk and menopausal age on women’s increased risk for AD

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Compétition

    Alzheimer’s Association International Grant Program

  • Province

    Ontario

  • Date de Début

    2023

  • Montant total du financement

    $199,540

  • Contribution Santé Canada

    $90,700

Aperçu du projet

Two-thirds of individuals suffering from Alzheimer’s disease are women. The reason for women’s increased risk of Alzheimer's disease is unknown. Menopause occurs when a decline in a hormone called estrogen causes middle-aged women to stop having menstrual periods. Early menopause can increase the risk of Alzheimer's disease. Vascular conditions, such…

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Targeting KCC2 for rescuing functional impairments in Alzheimer’s disease

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Compétition

    Alzheimer’s Association International Grant Program

  • Province

    Québec

  • Date de Début

    2024

  • Montant total du financement

    $200,000

  • Contribution Santé Canada

    $100,000

Aperçu du projet

Background Within the brain, cells communicate by sending signals that either enhance or dampen the activity of other cells. Balancing these excitatory and inhibitory signals is vital for the brain to function. Many components maintain this balance, but one key player is the protein KCC2. As levels of KCC2 are…

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Self-disclosure about dementia on social media: evidence-informed guidance

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Compétition

    Alzheimer’s Association International Grant Program

  • Province

    British Columbia

  • Date de Début

    2023

  • Montant total du financement

    $149,666

  • Contribution Santé Canada

    $68,031

Aperçu du projet

Individuals who engage on social media often disclose a personal dementia diagnosis or identify as a caregiver, yet little is known about the impact of that disclosure. The goal of this project is to address this gap and develop a resource to support users to navigate social media. We will…

Projet en cours

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A Drug Screening Assay to Reduce LINGO-1 Amounts in Neurons

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Compétition

    Alzheimer’s Association International Grant Program

  • Province

    Québec

  • Date de Début

    2022

  • Montant total du financement

    $150,000

  • Contribution Santé Canada

    $75,000

Aperçu du projet

The LINGO-1 protein is strongly associated with Alzheimer’s disease and is a novel drug target. LINGO-1 is a transmembrane protein that negatively regulates neuronal survival and myelination. LINGO-1 inhibition increases survival of multiple neural types and improves spatial learning, memory, and cognitive abilities in multiple mouse models. Thus, we hypothesize…

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