693 ésultat(s) trouvé(s)
Dopaminergic modulation of stroke recovery
Aperçu du projet
Strokes often cause brain damage that affects normal cognitive and sensorimotor functions. The brain has the extraordinary ability to adapt by forming new circuits which can, to some extent, compensate for neuronal loss. The recovery of motor function can be improved by rehabilitation exercises aimed at strengthening the brain and…
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Voir le projet et les chercheursMolecular origins of childhood brain cancer
Aperçu du projet
Pediatric high-grade gliomas are incurable brain cancers. Sequencing the tumor specimens has shown that most cases do not have obvious mutations that are known to cause cancer. It is therefore not known what causes, or "drives," these cancers. Identifying cancer drivers is a fundamental step in designing new treatments. We…
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Voir le projet et les chercheursIndividually Tailored Prediction of Treatments Response in Alzheimer’s Disease: 3 clinical trials validation
Aperçu du projet
Late-onset Alzheimer’s (late-AD) is a complex neurodegenerative condition with abnormalities in toxic protein accumulation, vascularization, inflammation, neuronal activity and cerebral atrophy. In keeping with the tenets of Personalized Medicine, treatments should be tailored to individual therapeutic needs as opposed to treating all patients with the same approach. In Neurodegeneration, unfortunately,…
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Voir le projet et les chercheursMolecular and behavioural assessment of a potential fetal Cannabis spectrum disorder in the rat
Aperçu du projet
Canada recently became the first G7 nation to legalize Cannabis for medicinal and recreational use. There is a recent and growing false belief that Cannabis can reduce nausea during pregnancy without harmful side effects on the fetus. This belief is not based in scientific research, of which there is very…
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Voir le projet et les chercheursRelating hippocampal pathways to human learning
Aperçu du projet
The human experience is marked by constant learning. Moments of contention, when new experiences conflict with prior knowledge, often lead to the most meaningful learning. How do we successfully navigate these moments and gain new knowledge? In the current project, we aim to answer this question by characterizing (1) how…