Répertoire des subventions financées

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Novel biological agents in the treatment of amyotrophic lateral sclerosis based on progranulin/granulin structure

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS

  • Compétition

    CQDM-Brain Canada Call for Collaborative Research Projects on the Brain

  • Province

    Québec

  • Date de Début

    2025

  • Montant total du financement

    $814,900

  • Contribution Santé Canada

    $407,450

Aperçu du projet

Challenge: ALS (amyotrophic lateral sclerosis) is an incurable and invariably fatal motor neuron (MN) disease. Our challenge is to develop a biologic-therapy that slows, halts or functionally reverses ALS progression. Solution: ALS is characterized by the toxic mislocalization of a hyperphosphorylated form of TAR DNA binding protein-43 (TDP-43) within MNs.…

Projet en cours

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Connecting cellular signalling data with behavioural and clinical outcomes for 5-HT receptor ligands

  • Domaine de recherche

    Mental Health

  • Disease Area

    Mental illness

  • Compétition

    CQDM-Brain Canada Call for Collaborative Research Projects on the Brain

  • Province

    Québec

  • Date de Début

    2025

  • Montant total du financement

    $500,000

  • Contribution Santé Canada

    $250,000

Aperçu du projet

The Challenge: Current therapies for treating a number of mental health disorders – depression, anxiety, and PTSD, among them – adequately treat only a small fraction of afflicted patients. Promising new targets, despite strong rationales, have not improved this picture. As ketamine provided more than two decades ago, a breakthrough…

Projet en cours

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Elatus: Chronically Implantable Unit-Scale Microelectrode Array Neuromodulation Technology

  • Domaine de recherche

    Saisie

  • Disease Area

    Epilepsy

  • Compétition

    CQDM-Brain Canada Call for Collaborative Research Projects on the Brain

  • Province

    Québec

  • Date de Début

    2025

  • Montant total du financement

    $1,657,750

  • Contribution Santé Canada

    $828,875

Aperçu du projet

Challenge: Current DRE standard of care is either DBS (Medtronic, Boston Scientific), Vagus Nerve Stimulation (VNS - Livanova) or Responsive Nerve Stimulation (RNS - NeuroPace). These devices rarely eliminate seizures, and there is little to differentiate them from one another. Typically, median seizure reduction is 50-70% which, while statistically significant,…

Projet en cours

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A brain-specific approach to RNA therapeutics: developing a novel protein delivery strategy for the central nervous system

  • Domaine de recherche

    Central Nervous System

  • Compétition

    CQDM-Brain Canada Call for Collaborative Research Projects on the Brain

  • Province

    Québec

  • Date de Début

    2025

  • Montant total du financement

    $1,076,074

  • Contribution Santé Canada

    $538,037

Aperçu du projet

Challenge: Delivery of therapeutic proteins to the brain has been a longstanding barrier to CNS drug development. Protein replacement or supplementation strategies hold promise for multiple brain diseases, from enzyme-replacement for neuronopathic lysosomal disorders, to growth factor supplementation for neurodegeneration, to cytokine immunotherapy for brain cancers. However, most brain diseases…

Projet en cours

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Designing synthetic extracellular matrices to support neurodegenerative disease modeling

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Other

  • Compétition

    CQDM-Brain Canada Call for Collaborative Research Projects on the Brain

  • Province

    Québec

  • Date de Début

    2025

  • Montant total du financement

    $550,000

  • Contribution Santé Canada

    $275,000

Aperçu du projet

We propose to develop chemically defined synthetic extracellular matrices to support neural cells in longterm stable cell culture. Human induced pluripotent stem cells (hiPSCs) have revolutionized disease modeling and drug discovery. Enhanced 2D and 3D culture models have tremendous potential to enable hiPSC development with greater cellular maturity compared to…

Projet en cours

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