Répertoire des subventions financées

Detecting Behaviours of Risk in Nursing Homes using Deep Learning

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Many people with dementia (PwD) live in nursing homes, which often suffer from a lack of skilled staff to support and monitor the safety of residents. Behavioural and psychological symptoms of dementia are commonly seen as a result of this lack of support and can be associated with risk for…

From Space to Memory Under Pathological Tau

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Among the earliest signs of preclinical Alzheimer’s disease (AD) are navigation impairments and the presence of abnormal Tau (aTau) proteins in the entorhinal cortex (EC), a brain region that represents space and movement. As AD progresses aTau spreads to the subiculum (Sub), a key region for memory encoding and retrieval.…

Canadian Consortium on Neurodegeneration In Aging (CCNA) – Phase 2

Brain and cognitive effects of long-term gender affirming hormone therapy in aging trans women

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Trans women may take estradiol-based gender affirming hormone therapy (GAHT) into their old age. Yet, we know little about the long-term brain health effects of GAHT. We propose to further our understanding of the earliest causes and signs of cognitive and brain aging effects in women by exploring the effects…

Sex differences in the innate immune response associated with Parkinson’s Disease

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Age is the most important risk factor for Parkinson’s Disease (PD), followed by sex, with a higher risk in males. Studies show that brain inflammation occurs early in the disease and persists throughout its course. As such, inflammation is likely to contribute to the disease. In the brain, the main…