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The SLEEP HUB: an open science ecosystem for transforming sleep research
Aperçu du projet
The SLEEP HUB is an innovative platform aimed at advancing sleep research and fostering collaborations at various levels—local, national, and international. Developed by the Centre for Advanced Research in Sleep Medicine (CARSM) located in Montreal, it integrates three key resources: the Nights Bank, the Canadian Sleep Research Biobank, and the…
Projet en cours
Voir le projet et les chercheursThe NECTAr platform: A pan-Canadian platform dedicated to Neonatal hypoxic-ischemic Encephalopathy — For patient Care optimization, Training, and educAtion
Aperçu du projet
At birth, some babies suffer from a condition called birth asphyxia, where their brain and organs do not receive enough oxygen or blood, leading to hypoxic-ischemic encephalopathy (HIE). This life-threatening condition is responsible for 23% of babies’ deaths worldwide and often results in cerebral palsy and difficulties with learning and…
Projet en cours
Voir le projet et les chercheursNovel biological agents in the treatment of amyotrophic lateral sclerosis based on progranulin/granulin structure
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Challenge: ALS (amyotrophic lateral sclerosis) is an incurable and invariably fatal motor neuron (MN) disease. Our challenge is to develop a biologic-therapy that slows, halts or functionally reverses ALS progression. Solution: ALS is characterized by the toxic mislocalization of a hyperphosphorylated form of TAR DNA binding protein-43 (TDP-43) within MNs.…
Projet en cours
Voir le projet et les chercheursConnecting cellular signalling data with behavioural and clinical outcomes for 5-HT receptor ligands
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The Challenge: Current therapies for treating a number of mental health disorders – depression, anxiety, and PTSD, among them – adequately treat only a small fraction of afflicted patients. Promising new targets, despite strong rationales, have not improved this picture. As ketamine provided more than two decades ago, a breakthrough…
Projet en cours
Voir le projet et les chercheursElatus: Chronically Implantable Unit-Scale Microelectrode Array Neuromodulation Technology
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Challenge: Current DRE standard of care is either DBS (Medtronic, Boston Scientific), Vagus Nerve Stimulation (VNS - Livanova) or Responsive Nerve Stimulation (RNS - NeuroPace). These devices rarely eliminate seizures, and there is little to differentiate them from one another. Typically, median seizure reduction is 50-70% which, while statistically significant,…