Répertoire des subventions financées

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558 ésultat(s) trouvé(s)

Dynamic palmitoylation regulates TDP-43 nucleocytoplasmic transport in ALS

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Bourses de découverte

  • Province

    Québec

  • Date de Début

    2024

  • Montant total du financement

    $125,000

Aperçu du projet

Common features in amyotrophic lateral sclerosis (ALS) include misdirected proteins that build up over time and lead to large protein clumps that are toxic to the cell and lead to cell death. In ALS, special cells known as motor neurons are particularly affected. These neurons have very long extensions known…

Projet en cours

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Role of neurofilament NFL depletion in TDP-43-mediated pathogenesis

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Bourses de découverte

  • Province

    Québec

  • Date de Début

    2024

  • Montant total du financement

    $125,000

Aperçu du projet

his proposal is based on our finding of substantial depletion of neurofilament synthesis in mouse models of ALS with abnormal accumulations of TDP-43, a hallmark of the disease. This is due to a selective block of NF-L synthesis on ribosome machinery that is explained by the binding of excess cytoplasmic…

Projet en cours

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Developing machine learning models of disease progression and survival outcomes in ALS patients: evaluating the utility of structural brain MRI as an ALS biomarker

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Bourses de découverte

  • Province

    Québec

  • Date de Début

    2024

  • Montant total du financement

    $125,000

Aperçu du projet

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately the death of the patient. While it is known that patients with ALS experience changes in certain brain regions, the relationships between these brain-related changes, patient symptoms, and survival…

Projet en cours

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Therapeutic validation of gene-based strategies aimed at restoring neuronal KCC2 in ALS

  • Type de programme

    Capacity building grants

  • Domaine de recherche

    Neurodegeneration

  • Compétition

    Society canadienne de la SLA - Fondation Brain Canada - Bourse de transition de carrière

  • Province

    Québec

  • Date de Début

    2024

  • Montant total du financement

    $250,000

Aperçu du projet

An imbalance between excitation and inhibition is one of the earliest detectable features of amyotrophic lateral sclerosis (ALS). In fact, changes in the inhibitory synaptic system appears to be central to this imbalance and the modulation of this system using potassium-chloride co-transporter 2 (KCC2)-enhancing compounds have proven to be an…

Projet en cours

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Investigating disease progression and survival outcomes in ALS patients using deep learning and deformation based morphometry

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    Québec

  • Date de Début

    2023

  • Montant total du financement

    $78,000

Aperçu du projet

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately the death of the patient. While it is known that patients with ALS experience brain changes, particularly in motor areas, the relationships between brain-related changes, patient symptom profiles, and…

Projet en cours

Voir le projet et les chercheurs