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Décryptage des fonctions biologiques de l’eEF2K pour le ciblage thérapeutique des tumeurs neurales

Aperçu du projet

In childhood, medulloblastoma (a form of brain cancer) and neuroblastoma (a cancer that starts in the nerve cells) can be aggressive and hard to treat. Dr Poul Sorensen’s group is targeting what he believes is the Achilles heel of tumour cells: namely, how they adapt and survive under stress. He has discovered that an enzyme called eEF2K helps cancer cells cope with stress and resist treatment. In this project, Dr Sorensen and his team will determine how eEF2K protects brain cells under stress and test whether blocking the enzyme will make cancer cells sensitive to therapy. This work could lead to more effective and targeted treatment options for childhood brain and neural cancers.

Chef d'équipe

Poul Sorensen , University of British Columbia

Partenaire et Donateurs

Canadian Cancer Society

Projet en cours

Décryptage des fonctions biologiques de l’eEF2K pour le ciblage thérapeutique des tumeurs neurales

  • Type de programme

    Team grants

  • Domaine de recherche

    Cancer

  • Disease Area

    Brain Cancer

  • Compétition

    Canadian Cancer Society Impact Grants

  • Province

    British Columbia

  • Date de Début

    2015

  • Montant total du financement

    $1,250,000

  • Contribution Santé Canada

    $625,000