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Nouveaux mécanismes cellulaires et moléculaires de régulation du dysfonctionnement de la synapse dans la maladie d’Alzheimer

Aperçu du projet

In Alzheimer s disease (AD), critical synaptic connections between neurons disintegrate and cells die. The brains of individuals with AD accumulate plaques of a protein fragment called AΠ that disrupt synapse function and cause neuronal death. Dr. Kennedy and his team will study a protein called netrin-1 that promotes cell survival, synapse formation, and synaptic changes underlying memory. Netrin-1 also binds AΠ and its precursor, Amyloid Precursor Protein (APP). APP acts similarly to netrin-1; however, AΠ does the opposite, disrupting synapses and killing neurons. The team will test the idea that APP is a receptor for netrin-1 at synapses in the healthy brain, but that in AD AΠ steals netrin-1 away from APP, thereby disrupting synapse function. Biochemical techniques, neuronal cell culture, electrophysiology, and live-imaging will be employed to assess the effects of AΠ, APP, and netrin-1 on synapse function. The proposed studies will help to understand how to maintain and promote synapse function in AD.

Chef d'équipe

Timothy Kennedy , McGill University

Partenaire et Donateurs

Alzheimer Society of Canada

Projet terminé

Nouveaux mécanismes cellulaires et moléculaires de régulation du dysfonctionnement de la synapse dans la maladie d’Alzheimer

  • Type de programme

    Capacity building grants

  • Domaine de recherche

    Neurodevelopment

  • Disease Area

    Alzheimer’s

  • Compétition

    Programme de recherche de la Société Alzheimer (PRSA)Subvention nouveau chercheur & réorientation de carrière

  • Province

    Québec

  • Date de Début

    2015

  • Montant total du financement

    $224,952

  • Contribution Santé Canada

    $112,476