Aller au contenu
Répertoire des projets
  • English
Faire un don maintenant
  • English
  • À propos
    • Ce que nous faisons
    • Leadership
    • Équipe
    • Publications
    • Carrières
  • Maladies du cerveau
    • Un cerveau
    • SLA
    • Alzheimer
    • Autisme
    • Cancer du cerveau
    • Traumatisme cranio-cérébral
    • Épilepsie
    • Troubles de santé mentale
    • Sclérose en plaques
    • Parkinson
    • AVC
    • Autre
  • Recherche
    • Programmes
    • Perspectives de financement
    • Partenaires de programmes
    • Annonces
  • Nouvelles sur l’impact
  • Façons de donner
    • Votre impact
    • Comment aider
    • Événements

Travaux subventionnés

Retour aux résultats

Safety and feasibility of focused ultrasound-enabled liquid biopsy in patients with brain tumours

Aperçu du projet

Need for project: Neuropathological diagnoses of brain tumours require invasive neurosurgical biopsies that carry a risk of morbidity or mortality to patients. There has been growing interest in the use of non-invasive liquid biopsies to sample cell-free circulating tumor DNA (ctDNA) for genomic and epigenomic analyses but the abundance of ctDNA in systemic circulation for brain tumour patients is relatively lower than that for systemic cancer patients, limiting sensitivity in this population. Goal of project: We aim to increase the sensitivity of non-invasive biopsy for the brain in a cohort of human subjects by increasing DNA shedding from the tumor into circulation using MRI guided focused ultrasound (MRgFUS). We hypothesize that sensitivity for identifying genomic and epigenomic biomarkers will improve with the increased availability of ctDNA after the application of MRgFUS Project description: MRgFUS causes a significant increase in temperature in a defined focal plane of the multiple (up to 1024) ultrasound beams. We aim to thermally ablate the tumor margin with MRgFUS to disrupt the BBB and allow permeabilization of tumor cell membranes and vessel walls for tumor DNA release into circulation. Plasma samples will be obtained from radiologically diagnosed tumor patients before and after MRgFUS and the accuracy in detecting genomic/epigenomic biomarkers will be compared. Future impact: The overarching goal of this project is to shift the paradigm of brain tumor diagnoses from high-risk invasive procedures to non-invasive diagnostic approaches with potentially additional advantages including the reaching of surgically inaccessible brain regions, capturing tumor al heterogeneity, serial monitoring for tumor progression, and distinguishing tumor from pseudoresponse, presudo progression, or radiation necrosis.

Chef d'équipe

Andres Lozano , University Health Network

Membres de l'équipe

Daniel De Carvalho, Princess Margaret center – UHN

Gelareh Zadeh, University Health Network, Princess Margaret, University of Toronto

Partenaire et Donateurs

Projet en cours

Safety and feasibility of focused ultrasound-enabled liquid biopsy in patients with brain tumours

  • Type de programme

    Team grants

  • Domaine de recherche

    Cancer

  • Disease Area

    Brain Cancer

  • Compétition

    CCS/CIHR/BC Spark Grant: Novel Technology Applications in Cancer Prevention and Early Detection

  • Province

    Ontario

  • Date de Début

    2021

  • Montant total du financement

    $150,000

  • Contribution Santé Canada

    $75,000

Contactez-nous

1200 Avenue McGill College
Bureau 1600, Montréal (Québec)
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

Balado : Playing with Marbles

Joignez-vous à nous en expédition vers l’ultime frontière, le cerveau.

Écouter

S’inscrire aux Brain News

Recevez notre infolettre électronique mensuelle incluant des mises à jour sur les projets financés, les événements à venir et les percées dans la recherche sur le cerveau.

S’inscrire

© 2023 Fondation Brain Canada

Numéro d’enregistrement : 89105 2094 RR0001

  • Modalités et conditions
  • Politique relative à la protection de la vie privée

Conception Field Trip & Co