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Inhibition synaptique dans le cortex moteur d’un modèle murin de la SLA

Aperçu du projet

ALS is a disease characterized by degeneration of both upper and lower motor neurons. Upper motor neurons are located in a region of the brain called the motor cortex and have been far less extensively studied than lower motor neurons in the spinal cord. One of the earliest detectable abnormalities in mouse models of ALS is differences in electrical activity at the motor cortex where upper motor neurons are firing signals excessively. As a result, some hypothesize that this excessive firing (called hyperexcitability), might cause the disease. Dr. Woodin is an experienced neurophysiologist who will utilize her expertise to study the underlying causes of this hyperexcitability and to then attempt a novel method for rescuing the effect.  Not only will this grant usher Dr. Woodin’s lab into the ALS community, but the results form the potential to discover a new therapeutic avenue for the disease.

Chef d'équipe

Melanie Woodin , University of Toronto

Partenaire et Donateurs

ALS Society of Canada

Projet terminé

Inhibition synaptique dans le cortex moteur d’un modèle murin de la SLA

  • Type de subvention

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Bourses de découverte

  • Province

    Ontario

  • Date de Début

    2015

  • Montant total du financement

    $100,000

  • Contribution Santé Canada

    $50,000