Répertoire des subventions financées

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692 ésultat(s) trouvé(s)

Démêler l’altération du système endocannabinoïde dans la SLA : une nouvelle méthode thérapeutique axée sur la jonction neuromusculaire

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS

  • Compétition

    Society canadienne de la SLA - Fondation Brain Canada - Bourse de transition de carrière

  • Province

    Québec

  • Date de Début

    2025

  • Montant total du financement

    $250,000

  • Contribution Santé Canada

    $125,000

Aperçu du projet

A hallmark and the earliest event taking place in ALS is the denervation of neuromuscular junctions (NMJs), which results in muscle weakness and paralysis. Results from mentor’s lab and others demonstrated that NMJ denervation in ALS is a complex and dynamic process rather than just a manifestation of sudden global…

Linking reduced cell-specific inhibition to abnormal brain activity in chronic stress

  • Type de subvention

    Team grants

  • Domaine de recherche

    Mental Health

  • Disease Area

    Mental illness

  • Compétition

    Brain Canada & Weizmann Institute of Science Team Grants

  • Province

    Ontario

  • Date de Début

    2025

  • Montant total du financement

    $500,000

  • Contribution Santé Canada

    $250,000

Aperçu du projet

Depression is a leading cause of disability, with a large proportion of treatment-resistant patients. Recent studies have implicated reduced brain inhibition in human depression from a specific neuron type (SST), and new pharmacology boosting this reduced inhibition led to antidepressant and pro-cognitive effects in rodents. However, establishing a direct link…

Harnessing mRNA translation to increase the neuroprotective potential of disease-associated microglia in neurodegenerative diseases

  • Type de subvention

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Compétition

    Brain Canada & Weizmann Institute of Science Team Grants

  • Province

    Québec

  • Date de Début

    2024

  • Montant total du financement

    $500,000

  • Contribution Santé Canada

    $250,000

Aperçu du projet

Microglia are the brain's immune cells. Research in recent years has revealed their crucial role in preventing the development of neurodegenerative diseases, including Alzheimer's Disease (AD). However, the precise mechanisms by which microglia lose their potency in protecting the brain, enabling the development of AD, are not fully understood. Our…

Deciphering the link between gut bacteria and glymphatics in neurodegeneration

  • Type de subvention

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS

  • Compétition

    Brain Canada & Weizmann Institute of Science Team Grants

  • Province

    Alberta

  • Date de Début

    2024

  • Montant total du financement

    $500,000

Aperçu du projet

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease in humans. The disease is caused by the degeneration of motor neurons that innervate the voluntary muscles, leading to respiratory failure and death within about 3 years from onset. A central feature of ALS is the abnormal…

Enhancing walking recovery after stroke through a 24-hour behaviour change approach

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Accident vasculaire cérébral et lésion cérébrale

  • Disease Area

    Stroke

  • Province

    Alberta

  • Date de Début

    2024

  • Montant total du financement

    $60,000

  • Contribution Santé Canada

    $30,000

Aperçu du projet

We are looking at how a behaviour change program can help stroke survivors recover their ability to walk better. We are aiming to recruit 24 people who have had a stroke within the first week after it happened. These participants need to be at least 18 years old, able to…