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Therapeutic validation of gene-based strategies aimed at restoring neuronal KCC2 in ALS

  • Type de programme

    Capacity building grants

  • Domaine de recherche

    Neurodegeneration

  • Compétition

    Society canadienne de la SLA - Fondation Brain Canada - Bourse de transition de carrière

  • Province

    Québec

  • Date de Début

    2024

  • Montant total du financement

    $250,000

Aperçu du projet

An imbalance between excitation and inhibition is one of the earliest detectable features of amyotrophic lateral sclerosis (ALS). In fact, changes in the inhibitory synaptic system appears to be central to this imbalance and the modulation of this system using potassium-chloride co-transporter 2 (KCC2)-enhancing compounds have proven to be an…

Investigating disease progression and survival outcomes in ALS patients using deep learning and deformation based morphometry

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    Québec

  • Date de Début

    2023

  • Montant total du financement

    $78,000

Aperçu du projet

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately the death of the patient. While it is known that patients with ALS experience brain changes, particularly in motor areas, the relationships between brain-related changes, patient symptom profiles, and…

Profiling Cortical Excitability in ALS Using Threshold Tracking Transcranial Magnetic Stimulation and Multimodal Biomarkers

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    Ontario

  • Date de Début

    2023

  • Montant total du financement

    $75,000

Aperçu du projet

Rationale: Cortical hyperexcitability has been identified to be a potential driver of ALS pathology leading to excitotoxicity and degeneration of upper motor neurons (UMNs)in the primary motor cortex (M1) and the subsequent degeneration of lower motor neurons (LMNs) in the spinal cord. Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological…

Determining the contribution of acute viral infection on the onset and progression of ALS

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    Ontario

  • Date de Début

    2023

  • Montant total du financement

    $25,000

Aperçu du projet

Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43 is an RNA-binding protein that regulates RNA expression and function, including mRNA translation. The mechanisms by which TDP-43 pathology contributes to ALS remain incompletely understood, hampering the development of a rational therapy…

Defective protein translation: a causative pathway in ALS?

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    British Columbia

  • Date de Début

    2023

  • Montant total du financement

    $75,000

Aperçu du projet

Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43 is an RNA-binding protein that regulates RNA expression and function, including mRNA translation. The mechanisms by which TDP-43 pathology contributes to ALS remain incompletely understood, hampering the development of a rational therapy…