Répertoire des subventions financées

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Investigating TDP-43 palmitoylation as a therapeutic target to lower protein aggregation

  • Type de programme

    Capacity building grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    ALS Canada-Brain Canada Trainee Program 2022

  • Province

    Ontario

  • Date de Début

    2022

  • Montant total du financement

    $75,000

  • Contribution Santé Canada

    $37,500

Aperçu du projet

TDP-43 (transactive response DNA-binding protein 43) is one of the few genes highly associated with ALS (amyotrophic lateral sclerosis). Although TDP-43 mutations only occur in a small subset of ALS patients, cytoplasmic inclusions that mainly consists of TDP-43 protein aggregates are present in 97% of all ALS cases as well…

Projet en cours

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Personalized medicine for Bipolar disorder: clinical lithium response as a guide to mode of action and biomarker discovery using human neurons and biofluids

  • Type de programme

    Team grants

  • Domaine de recherche

    Mental Health

  • Disease Area

    Mental illness

  • Compétition

    Bell Let’s Talk – Brain Canada Mental Health Research Program

  • Province

    Québec

  • Date de Début

    2022

  • Montant total du financement

    $950,000

  • Contribution Santé Canada

    $475,000

Aperçu du projet

Bipolar Disorder (BD) is a chronic psychiatric illness, ranking in the top 10 causes of disability and mortality worldwide, due to suicide and cardiovascular death. BD affects ~3% of the global population and >500,000Canadians. Typically, the disease starts during adolescence and has a life-long course, characterized by extreme states of…

Projet en cours

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Precision in Space and Time: Brain State-Dependent Stimulation Using Real-Time EEG and TMS

  • Type de programme

    Capacity building grants

  • Domaine de recherche

    Mental Health

  • Disease Area

    Mental illness

  • Compétition

    Future Leaders in Canadian Brain Research

  • Province

    Ontario

  • Date de Début

    2022

  • Montant total du financement

    $100,000

  • Contribution Santé Canada

    $50,000

Aperçu du projet

The goal of this project is to develop new principles to treat brain disease and investigate brain function using non-invasive neurostimulation, without the side-effects of drugs. Neurostimulation is already an established treatment for many neurological and psychiatric disorders, such as major depression disorder, but the effectiveness of the method is…

Projet en cours

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Sex bias in autism spectrum disorders: Examining how sexual differentiation leads to divergent neurodevelopment and social behaviour

  • Type de programme

    Capacity building grants

  • Domaine de recherche

    Neurodevelopment

  • Disease Area

    Other

  • Compétition

    Future Leaders in Canadian Brain Research

  • Province

    Newfoundland and Labrador

  • Date de Début

    2022

  • Montant total du financement

    $100,000

  • Contribution Santé Canada

    $50,000

Aperçu du projet

Males are 4X more likely than females to develop Autism Spectrum Disorder (ASD), suggesting that the biology of sex development contributes to the risk of developing this neurodevelopmental condition. We will assess whether the Y chromosome and androgens—both of which contribute to male-typical development—underlie the greater risk for ASD among…

Projet en cours

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Targeting GRP78 palmitoylation in glioblastomas

  • Type de programme

    Capacity building grants

  • Domaine de recherche

    Cancer

  • Disease Area

    Brain Cancer

  • Compétition

    Future Leaders in Canadian Brain Research

  • Province

    Ontario

  • Date de Début

    2022

  • Montant total du financement

    $100,000

  • Contribution Santé Canada

    $50,000

Aperçu du projet

Glioblastoma multiforme (GBM) the most common form of brain cancer in adults with very low survival of only 15 months with less than 5% of patients surviving more than 5 years. Surgery, chemotherapy, and radiation are the treatments currently used but recurrence is very common, often with tumors that are…

Projet en cours

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