Répertoire des subventions financées

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Targeting the immune suppressive microenvironment in histone 3-mutant high-grade gliomas

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Cancer

  • Disease Area

    Brain Cancer

  • Compétition

    CRS Operating Grants

  • Province

    Québec

  • Date de Début

    2024

  • Montant total du financement

    $130,000

  • Contribution Santé Canada

    $65,000

Aperçu du projet

The immune system is responsible for protecting the body against diseases, but it can also play a role in tumor formation. By exploring the role of these cells in cancer, we can understand how they promote tumor progression. In this project, our goal is to modify the activity of a…

Projet en cours

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Impact of 2-hydroxyglutarate-induced astrocytes reactivity in low-grade glioma progression and recurrence

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Cancer

  • Disease Area

    Brain Cancer

  • Compétition

    CRS Operating Grants

  • Province

    Québec

  • Date de Début

    2024

  • Montant total du financement

    $130,000

  • Contribution Santé Canada

    $65,000

Aperçu du projet

Mutations in the metabolic enzymes are commonly observed in brain cancers. Although the precise molecular underpinning for this remains elusive, it has been shown that brain cancer-associated mutations in metabolic pathways confer altered metabolic function by increasing production of the oncogenic metabolite R-2-Hydroxyglutarate (R-2HG). This metabolite was shown to promote…

Projet en cours

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Specific translation of mRNAs encoding primary cilia components as a new resistance mechanism in glioblastoma

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Cancer

  • Disease Area

    Brain Cancer

  • Compétition

    CRS Operating Grants

  • Province

    Ontario

  • Date de Début

    2024

  • Montant total du financement

    $130,000

  • Contribution Santé Canada

    $65,000

Aperçu du projet

We are studying a type of brain tumour called glioblastoma (GBM), which is often fatal despite current treatments. Our team developed a new technique to analyze a specific part of the tumour's molecular makeup and found three subtypes with different survival rates. One subtype, called "Ciliary," stands out because of…

Projet en cours

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Identification of the Neural Circuitry of Persistent Depressive Symptoms in First-Episode Schizophrenia: From Biomarkers to Predictive Imaging

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Mental Health

  • Disease Area

    Mental illness

  • Compétition

    Rising Stars Trainee Awards

  • Province

    Ontario

  • Date de Début

    2024

  • Montant total du financement

    $12,000

  • Contribution Santé Canada

    $6,000

Aperçu du projet

People with schizophrenia often suffer from depressive and negative symptoms, such as reduced emotional expression, or less motivation. These symptoms can have a significant impact on their risk of suicide, prognosis, and overall quality of life. The fact that depressive and negative symptoms in schizophrenia have a lot in common…

Projet en cours

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Brain-heart dynamics in treatment-resistant depression and the effects of repetitive transcranial magnetic stimulation

  • Type de subvention

    Capacity building grants

  • Domaine de recherche

    Mental Health

  • Disease Area

    Mental illness

  • Compétition

    Rising Stars Trainee Awards

  • Province

    British Columbia

  • Date de Début

    2024

  • Montant total du financement

    $12,000

  • Contribution Santé Canada

    $6,000

Aperçu du projet

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation therapy, recommended by Canadian guidelines as a first-line intervention for major depression that does not respond to an adequate course of pharmacological therapy, known as treatment-resistant depression (TRD). rTMS applies a series of pulses to the prefrontal cortex, leading to changes…

Projet en cours

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