Répertoire des subventions financées

Rôle de la kinase c-Src mitochondriale dans la maladie d’Alzheimer

Aperçu du projet

Mitochondrial dysfunctions are observed before and during the progression of Alzheimer's disease (AD). It is important to understand how the regulation of mitochondria is impaired in AD. The c-Src kinase has appeared as an important regulator of mitochondria. The aim of this research program is to explore, for the first…

Suivi de la progression de la maladie d’Alzheimer dans ses premiers stades : un projet multimodal

Aperçu du projet

New neuroimaging techniques enable us to measure the key hallmarks of Alzheimer's disease (AD) pathology before symptoms appear. The AD pathologic process is known to begin decades before the appearance of dementia symptoms such as memory or language deficits. Therefore, Dr. Villeneuve will use these new imaging methods alongside existing…

The interplay of DNA regulatory elements and epigenetics in Alzheimer’s disease

Nouveaux mécanismes cellulaires et moléculaires de régulation du dysfonctionnement de la synapse dans la maladie d’Alzheimer

Aperçu du projet

In Alzheimer s disease (AD), critical synaptic connections between neurons disintegrate and cells die. The brains of individuals with AD accumulate plaques of a protein fragment called AΠ that disrupt synapse function and cause neuronal death. Dr. Kennedy and his team will study a protein called netrin-1 that promotes cell…

Les souches d’agrégats A-beta dans la maladie d’Alzheimer 

Aperçu du projet

The existence of different strains of misshapen proteins in the brains of Alzheimer’s disease (AD) patients is emerging as an obstacle to the development of effective treatments. Recent research has revealed that the proteins that accumulate in the brain during AD are reminiscent of prions, which cause rare brain diseases…